Chimeric Mice with Humanized Liver

Chimeric mice with humanized liver: tools for the study of drug ...

Recent developments in animal models have allowed the creation of mice with genetic alterations that cause hepatocyte damage that results, over time, ...

Humanized Liver Mouse Models for Translational Preclinical Research

PXB-mice have up to 95% human hepatocyte engraftment in the liver, and express stable blood levels of human albumin, a biomarker of humanization, over their ...

Chimeric Mice with Humanized Liver: Tools for the Study of Drug ...

Fig. 27.1. ... Humanized mouse liver model (FRG). A deficiency in Fah activity leads to the accumulation of metabolites of tyrosine that are toxic to native ...

Humanized liver TK-NOG mice with functional deletion of hepatic ...

Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans.

Chimeric mice with humanized liver - ScienceDirect.com

We thought that chimeric mice with humanized liver could become a new tool for estimating the human toxicity and pharmacokinetics.

Characterization and applications of chimeric mice with humanized ...

Chimeric mice with humanized livers and human hepatocytes isolated from these mice have immense potential in future applications, such as for ...

Mice With Human Livers - Gastroenterology

Keywords: Hepatocyte; Liver; Chimera; Humanization;. Animal Model. Chimeric mice harboring human cells have long been used in research. The first examples were ...

Humanized Liver Rodent Models - Hera BioLabs

Humanized liver rat and mice are created by ablation of native hepatocytes through either chemical or genetic alterations that cause hepatocyte ...

A human liver chimeric mouse model for non-alcoholic fatty liver ...

This humanised NAFLD model is a physiologically relevant, experimentally tractable model for the study of steatosis.

Chimeric Mice With Humanized Livers Demonstrate Human-Specific ...

In this study, we investigated the hepatotoxicity caused by KMTR2, an anti-human TRAIL-R2 monoclonal antibody, in chimeric mice with humanized livers (PXB-mice ...

Mice With Human Livers - Gastroenterology

The liver plays a central role in many human-specific biological processes and mice with humanized livers can be used to model human metabolism, liver injury, ...

Application of Chimeric Mice with Humanized Liver for Study of ...

We evaluated a recently developed chimeric mouse model with humanized liver on uPA/SCID background for its ability to predict human disposition of four model ...

Generation of Novel Chimeric Mice with Humanized Livers by Using ...

These results indicate that hemizygous cDNA-uPA/SCID mice may be novel and useful hosts for producing chimeric mice for use in future long-term studies.

New applications of chimeric mice with humanized livers

Unfortunately, little is known about the metabolic capacity of cultivated human hepatocytes compared to their performance in chimeric mouse ...

Can 'humanized' mice improve drug development in the 21st century?

Chimeric mice, which have human hepatocytes engrafted in their liver, have been used to study human drug metabolism and pharmacodynamic responses for nearly 20 ...

Combining Chimeric Mice with Humanized Liver, Mass ...

(14) Chimeric mice with humanized liver revealed that the second oxidation step in the human disproportionate 5-hydroxythalidomide pathway ...

Humanization of Excretory Pathway in Chimeric Mice with ...

We previously reported that the chimeric mice with humanized liver could be useful as a human model in studies on drug metabolism and pharmacokinetics. In the ...

EXPRESSION OF HUMAN PHASE II ENZYMES IN CHIMERIC MICE ...

We clarified that major human cytochrome P450 (P450) enzymes were expressed in a chimeric mouse line established recently in Japan, in which the liver could be ...

A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

We performed in vivo and in vitro studies to determine the induction of human cytochrome P450 (CYP) using chimeric mice with humanized liver (PXB-mice®) and ...

Assessment of chimeric mice with humanized livers in new drug ...

1. Chimeric mice with humanized livers are expected to be a novel tool for new drug development. This review discusses four applications where these animals ...