Chimeric mice with humanized liver

Chimeric mice with humanized liver: tools for the study of drug ...

Recent developments in animal models have allowed the creation of mice with genetic alterations that cause hepatocyte damage that results, over time, ...

Humanized Liver Mouse Models for Translational Preclinical Research

PXB-mice have up to 95% human hepatocyte engraftment in the liver, and express stable blood levels of human albumin, a biomarker of humanization, over their ...

Chimeric Mice with Humanized Liver: Tools for the Study of Drug ...

Fig. 27.1. ... Humanized mouse liver model (FRG). A deficiency in Fah activity leads to the accumulation of metabolites of tyrosine that are toxic to native ...

Chimeric mice with humanized liver - ScienceDirect.com

The chimeric mice have been shown to exhibit a humanized profile of drug metabolism, induction and inhibition of drug metabolizing enzymes, and excretion in in ...

Humanized liver TK-NOG mice with functional deletion of hepatic ...

Chimeric TK-NOG mice with a humanized liver (normal Hu-liver) are a unique animal model for predicting drug metabolism in humans.

Characterization and applications of chimeric mice with humanized ...

Chimeric mice with humanized livers and human hepatocytes isolated from these mice have immense potential in future applications, such as for ...

Humanized Liver Rodent Models - Hera BioLabs

The resulting humanized liver chimeric animal is an excellent model for studying in-vivo liver toxicity, drug transport, drug-drug interactions ...

Mice With Human Livers - Gastroenterology

Keywords: Hepatocyte; Liver; Chimera; Humanization;. Animal Model. Chimeric mice harboring human cells have long been used in research. The first examples were ...

Chimeric mice with humanized liver: Application in drug metabolism ...

Since human drug metabolizing enzymes are expressed in the liver of these mice, they are regarded as suitable models for mimicking the drug metabolism and PK ...

Chimeric Mice With Humanized Livers Demonstrate Human-Specific ...

Chimeric mice with humanized liver such as PXB-mice can be novel tools for the evaluation of the in vivo human-specific hepatotoxicity induced ...

Humanization of Excretory Pathway in Chimeric Mice with ...

We previously reported that the chimeric mice with humanized liver could be useful as a human model in studies on drug metabolism and pharmacokinetics. In the ...

Generation of Novel Chimeric Mice with Humanized Livers by Using ...

The generation of chimeric mice with humanized livers by transplantation of human hepatocytes (h-heps) into the spleen of urokinase-type plasminogen activator ( ...

New applications of chimeric mice with humanized livers

Unfortunately, little is known about the metabolic capacity of cultivated human hepatocytes compared to their performance in chimeric mouse ...

Application of Chimeric Mice with Humanized Liver for Study of ...

We evaluated a recently developed chimeric mouse model with humanized liver on uPA/SCID background for its ability to predict human disposition ...

Can 'humanized' mice improve drug development in the 21st century?

Chimeric mice, which have human hepatocytes engrafted in their liver, have been used to study human drug metabolism and pharmacodynamic ...

Human Liver Chimeric Mice (HepMice) - Invivocue

The accumulation of lipids in hepatocytes is a hallmark feature of fatty liver disease. Treatment of human hepatocytes with increasing concentration of oleic ...

Chimeric Mouse with Humanized Liver Consortium Publications

Chimeric Mouse with Humanized Liver Consortium Publications ... As the liver is the primary site for drug metabolism, the PXB-mouse is the best ...

Culture density contributes to hepatic functions of fresh human ...

Chimeric mice with humanized livers are considered a useful animal model for predicting human (h-) drug metabolism and toxicity.

A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

We performed in vivo and in vitro studies to determine the induction of human cytochrome P450 (CYP) using chimeric mice with humanized liver (PXB-mice®) and ...

Chimeric Mouse With Humanized Liver Is an Appropriate Animal ...

However, an appropriate in vivo experimental model to evaluate an effect of porphyrinogenic compounds on human liver has not been fully ...