Circadian Clock Proteins Seized by Liver Cancer

The new findings are published in Proceedings of the National Academy of Sciences in a paper titled, “Circadian regulator BMAL1::CLOCK promotes ...

Study shows how liver cancer hijacks circadian clock machinery ...

Now, a study led by researchers at the Keck School of Medicine of USC not only directly links circadian clock proteins to liver cancer, but also ...

Preservation of circadian rhythm in hepatocellular cancer - PMC

These core clock proteins regulate thousands of tissue-specific genes. Regarding circadian control in neoplastic tissues, reports to date have ...

Circadian regulator BMAL1::CLOCK promotes cell proliferation in ...

Our findings establish anti-apoptotic roles of the master clock regulators BMAL1 and CLOCK in promoting proliferation of liver cancer cells and ...

Circadian regulator BMAL1::CLOCK promotes cell proliferation in ...

Hepatocellular carcinoma (HCC) remains a global health challenge whose incidence is growing worldwide. Previous evidence strongly supported ...

Liver Cancer Cells Hijack Mutated Circadian Clock Proteins to Grow ...

A new study reveals that circadian clock proteins are actively involved in the development of hepatocellular carcinoma (HCC) and provide a mechanistic ...

DNA polymerase beta connects tumorigenicity with the circadian ...

Disruption in circadian clock and DNA repair is closely linked with hepatocellular carcinoma (HCC) progression, but the mechanism remains unknown.

Integrative analysis indicates the prognostic value of circadian ...

Circadian rhythm disruption (CRD) is often associated with malignant tumor progression and poor prognosis. However, the effect of CRD on liver cancer prognosis ...

Circadian rhythms and inflammatory diseases of the liver and gut

Patients with HCC may have disruptions in genes involved in circadian homeostasis. The clock genes PER1 and RORα were differentially expressed in HCC tumor ...

Cancer and the Circadian Clock - AACR Journals

As observed, the pivotal tumor suppressor protein p53 is central to coupling circadian and cell-cycle oscillators. Molecular studies demonstrated that p53 ...

Incompatibility of the circadian protein BMAL1 and HNF4α ... - Nature

These data suggest that manipulation of the circadian clock in HNF4α-positive HCC could be a tractable strategy to inhibit tumor growth and ...

Interactions of circadian clock genes with the hallmarks of cancer

A strong relationship between circadian rhythm genes and various tumors, such as pancreatic, ovarian, lung, prostate, breast, colorectal, liver, non-Hodgkin's ...

Enhancing circadian clock function in cancer cells inhibits tumor ...

We found that clock genes were suppressed in B16 cells and tumors, but treatments inducing circadian rhythmicity, such as dexamethasone, ...

Circadian Clock Control of Liver Metabolic Functions

Also, tran- script levels of innate immunity proteins, many of which are synthesized in liver, have circadian rhythms. As a last example, the liver is a major ...

Body clock researchers prevent liver cancer growth in mice

The body's internal clock could play a critical role in the fight against certain types of liver cancer, according to a preclinical study by ...

Circadian regulator BMAL1::CLOCK promotes cell proliferation in ...

to leverage therapeutic strategies targeting clock proteins in HCC. ... novel liver cancer therapies via modulation of the circadian clock.

Circadian Clock, Cancer, and Chemotherapy - ACS Publications

The effect of the circadian clock on the DNA damage response and the related questions of circadian clock–cancer connections may be considered ...

Defining the Independence of the Liver Circadian Clock - Cell Press

High-throughput transcriptomics and metabolomics show that the liver has independent circadian functions specific for metabolic processes such ...

Genomics of circadian rhythms in health and disease

They examined the TSSs of the clock repressor gene Cryptochrome 1 (Cry1) and of a liver-specific clock-controlled gene, Gys2 (Glycogen ...

Integration of feeding behavior by the liver circadian clock reveals ...

We found that the cooperative action of BMAL1 and the transcription factor CEBPB regulates daily liver metabolic transcriptional programs.