Circadian clock features define novel breast cancer subtypes and ...

We demonstrate that the circadian clock plays a critical role in shaping pharmacological responses to various anti-cancer drugs and identify circadian features ...

This led to the identification of four distinct circadian-based phenotypes in breast cancer: functional, weak, unstable, and dysfunctional ...

Circadian clock features define novel breast cancer subtypes and ...

Request PDF | Circadian clock features define novel breast cancer subtypes and shape drug sensitivity | The circadian clock regulates key ...

Circadian clock features define novel breast cancer subtypes and ...

Observing diverse circadian dynamics, we developed metrics to assess circadian rhythm strength and stability. This led to the identification of ...

Circadian clocks and breast cancer - PMC - NCBI

One of the processes regulated by the circadian clock is the cell cycle. Disruption of circadian rhythms can therefore be associated with ...

CLOCK in breast tumorigenesis: evidence from genetic, epigenetic ...

These findings support the hypothesis that circadian genes may be relevant for tumorigenesis, and suggest that circadian gene variants may represent a novel ...

bioRxiv Cancer Bio on X: "Circadian clock features define novel ...

Circadian clock features define novel breast cancer subtypes and shape drug sensitivity https://t.co/cH3ExPRNJU #biorxiv_cancer.

A novel circadian cycle-related gene signature for prognosis

The extensive and intricate relationships between circadian rhythm and cancer have been reported in numerous studies. However, in breast ...

Major roles of the circadian clock in cancer

Several studies have revealed a close relationship between circadian rhythm disorders and cancer. A meta-analysis of various human cancer ...

Circadian oscillations persist in low malignancy breast cancer cells

This work also suggests that circadian rhythms are further disrupted in more aggressive/high tumor grades of breast cancer, and that use of real time ...

Circadian rhythm regulates the function of immune cells ... - Nature

These findings suggest a connection between dysregulated clock gene expression and T cell dysfunction in aging and cancer, implying that ...

Altered Circadian Rhythms and Breast Cancer: From the Human to ...

It was first reported in the 1960s that circadian rhythm disruptions can lead to an increased likelihood of mammary tumor development, and that circadian genes ...

A Non-canonical Function of BMAL1 Metabolically Limits Obesity ...

The epidemiological association between disrupted circadian rhythms and metabolic diseases is implicated in increased risk of human breast ...

Circadian PERformance in breast cancer: a germline and somatic ...

Polymorphisms in the PER3 gene have been associated with several human disease phenotypes, including sleep disorders and cancer.

Subtype-specific circadian clock dysregulation modulates breast ...

Studies in shift workers and model organisms link circadian disruption to breast cancer. Yet molecular rhythms in non-cancerous and ...

Circadian rhythm-related factors of PER and CRY family genes ...

The period (PER) and cryptochrome (CRY) families play critical roles in circadian rhythms. The imbalance of circadian factors may lead to the occurrence of ...

The Relationship between Circadian Rhythm and Cancer Disease

The circadian clock regulates biological cycles across species and is crucial for physiological activities and biochemical reactions, including cancer onset ...

Loss of circadian clock gene expression is associated with tumor ...

However, the association between circadian clock genes and prognosis in breast cancer has not been systematically studied. Therefore, we examined the expression ...

Targeting circadian transcriptional programs in triple negative breast ...

AbstractCircadian clock genes are emerging targets in many types of cancer, but their mechanistic contributions to tumor progression are still largely ...

Molecular subtypes and precision treatment of triple-negative breast ...

This figure shows the association of the transcriptomic TNBC subtypes with other tumor characteristics. The BLIS subtype is correlated with enrichment of HRD ...