Circulating Tumor DNA and Survival in Metastatic Breast Cancer

Detection of ctDNA was associated with worse overall, progression-free, and disease-free survival in patients with metastatic breast cancer.

Association of Circulating Tumor DNA With Disease-Free Survival in ...

In this systematic review and meta-analysis, elevated plasma ctDNA was associated with a high risk of relapse. This finding suggests that ...

Circulating tumor DNA validity and potential uses in metastatic ...

In studies on metastatic breast cancer, ctDNA has been utilized for treatment tailoring, tracking mechanisms of drug resistance, and for ...

Circulating Tumor DNA Profiling From Breast Cancer Screening ...

The frequency of ctDNA-positive samples was significantly higher in patients with metastatic disease compared with healthy controls, with overall survival ...

Significant impact of circulating tumour DNA mutations on survival in ...

Mutational analysis of circulating tumour (ct) DNA holds promise as an effective tool to predict the course of metastatic breast cancer (MBC).

Circulating Tumor DNA and Disease-Free Survival in Breast Cancer

Detection of ctDNA was statistically significantly associated with a reduction in DFS in both the early breast cancer subgroup (HR, 8.32; 95% CI ...

Rational thresholding of circulating tumor DNA concentration for ...

In metastatic breast cancer, ctDNA levels below (above) 10 copies/mL (100 copies/mL) have high NPV (PPV) for progression. •. Frequent long-term ...

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast ...

Therefore, there is an urgent need for biomarkers that measure tumor burden with high sensitivity and specificity. Cancer antigen 15-3 (CA 15-3) ...

Circulating tumor DNA: from discovery to clinical application in ...

In another extensive retrospective study involving patients with locally advanced breast cancer and metastatic breast cancer (MBC), the mean ...

The circulating tumor DNA (ctDNA) alteration level predicts ...

Especially in advanced or metastatic tumors, ctDNA has higher clinical value and development prospects because of its relatively high detection rate [7,9].

Circulating tumor DNA for predicting recurrence in patients with ...

The incorporation of circulating tumor DNA (ctDNA) into the management of operable breast cancer (BC) has been hampered by the heterogeneous ...

Serial monitoring of circulating tumor DNA in patients with primary ...

Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell‐free circulating tumor DNA (ctDNA) ...

Circulating tumor DNA in neoadjuvant-treated breast cancer reflects ...

Lack of ctDNA clearance was a significant predictor of poor response and metastatic recurrence, while clearance was associated with improved ...

Subtyping of metastatic breast cancer based on plasma circulating ...

A significant benefit from ctDNA alteration-guided treatment was observed in patients with NF and CSP ctDNA alterations, with hazard ratios of ...

Personalized Detection of Circulating Tumor DNA Antedates Breast ...

In breast cancer, previous studies have shown the potential utility of ctDNA to detect preclinical metastases and predict relapse following ...

A large-scale retrospective study in metastatic breast cancer patients ...

Purpose Monitoring levels of circulating tumor-derived DNA (ctDNA) represents a non-invasive snapshot of tumor burden and potentially clonal ...

Circulating tumor DNA for breast cancer: Review of active clinical trials

Circulating tumor DNA has been used to detect tumor burden and minimal residual disease in metastatic breast cancer. •. There are multiple uses of ctDNA that ...

Circulating Tumor DNA Predicts the Response and Prognosis in ...

Our study demonstrated that ctDNA can be used to predict tumor response to NAC and prognosis in early breast cancer.

Evaluation of Circulating Tumor DNA Levels as a Predictive Marker ...

Changing treatment earlier based on changing levels of ctDNA may increase the amount of time that a patient's metastatic breast cancer is controlled compared to ...

Analysis of circulating tumor DNA to monitor metastatic breast cancer.

This proof-of-concept analysis showed that circulating tumor DNA is an informative, inherently specific, and highly sensitive biomarker of metastatic breast ...