Cisplatin|Induced Ototoxicity

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

The incidence of ototoxicity induced by cisplatin has been estimated to be 36% of adult patients with cancer and 40%-60% of pediatric patients.

Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection ...

This review summarizes clinical and experimental studies of cisplatin ototoxicity, and focuses on understanding its toxicity mechanisms, clinical repercussions ...

Cisplatin ototoxicity mechanism and antagonistic intervention strategy

This article reviews the possible pathways and molecular mechanisms of cisplatin trafficking from peripheral blood into the inner ear, the toxic response of ...

Cisplatin Ototoxicity and Protection: Clinical and Experimental Studies

Although ototoxicity caused by cisplatin may occur within hours to days after drug administration, delayed ototoxicity from cisplatin may occur in children.

Preventing, Monitoring, and Managing Ototoxicity Related to Cisplatin

Cisplatin is a known ototoxic agent and can be associated with permanent, bilateral sensorineural hearing loss. In the review, Chattaraj et al ...

Cisplatin-induced ototoxicity: From signaling network to therapeutic ...

In this article, we preform a narrative review of the latest reported molecular mechanisms of cisplatin-induced ototoxicity, from extracellular to ...

A potential therapeutic approach for cisplatin-induced hearing loss

Protection from cisplatin-induced hearing loss with lentiviral vector-mediated ectopic expression of the anti-apoptotic protein BCL-XL

FDA Approval Marks New Era for Preventing Cisplatin-Induced ...

Roughly 60% of pediatric patients who are given cisplatin develop hearing loss, which is a permanent side effect that causes lifelong disability ...

The genetic vulnerability to cisplatin ototoxicity: a systematic review

These meta-analytic results from 30 studies are consistent with a view of a genetic predisposition to platinum-based chemotherapy mediated ototoxicity.

Mechanisms of Aminoglycoside- and Cisplatin-Induced Ototoxicity

Systemically administered aminoglycosides initially induce hair cell death in the outer cells of the basal, high-frequency region of the cochlea ...

Cisplatin-induced ototoxicity: Updates on molecular mechanisms ...

The incidence of ototoxicity induced by cisplatin ranges from 20% to 70%, and it usually manifests as a progressive, bilateral and irreversible hearing loss.

Molecular Characteristics of Cisplatin-Induced Ototoxicity and ...

Cisplatin-induced ototoxicity is characterized by bilateral, moderate-to-profound high-frequency hearing loss, and a significant loss of outer hair cells (OHCs) ...

Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

This review focuses on recent development in our understanding of the mechanisms underlying cisplatin-induced hearing loss and provides examples of how drug ...

Cisplatin-Induced Hearing Loss - Fennec Pharmaceuticals

Onset can occur early into treatment with cisplatin · Just 1 cisplatin treatment cycle can lead to a lifetime of hearing loss · Hearing can deteriorate even ...

The cumulative incidence of cisplatin‐induced hearing loss in young ...

In young children, the cumulative incidence of cisplatin-induced hearing loss is higher compared with that in older children and develops ...

Insight into the current practice of ototoxicity monitoring during ...

Cisplatin is considered one of the most ototoxic pharmacologic agents, typically causing bilateral high frequency sensorineural hearing loss ...

Cisplatin-Induced Ototoxicity | PEDMARK® (sodium thiosulfate ...

Cisplatin-induced ototoxicity puts many cancer patients at risk for lifelong hearing impairment · Understanding how cisplatin-induced ototoxicity occurs · The ...

Subclinical diagnosis of cisplatin-induced ototoxicity with biomarkers

Prestin has been found to be acutely elevated in the serum after a variety of ototoxic insults in previously published literature. Cisplatin, ...

Prevalence and risk factors for cisplatin-induced hearing loss in ...

Prevalence and risk factors for cisplatin-induced hearing loss in children, adolescents, and young adults: a multi-institutional North American cohort study

Risk factors associated with cisplatin‐induced ototoxicity in ...

Hearing impairment and tinnitus, which are also dose-dependent, occur at a high frequency and are the first to occur in cisplatin-treated ...