Cisplatin Toxicity in Children with Malignancy

Cisplatin, since its discovery, is an important drug in the treatment of children with cancer. However, its widespread use is limited by several ...

Risk Factors for Cisplatin-Associated Ototoxicity in Pediatric ...

The reported incidence of cisplatin-related ototoxicity in children ranges from 22% to 70% [1–4]. The severity of hearing loss appears to be worse at high ...

Identifying cisplatin-induced kidney damage in paediatric oncology ...

The closely related drug carboplatin is also used to treat childhood cancer, but its toxicity profile is clearly distinct from that of cisplatin ...

Cisplatin-Associated Nephrotoxic Effects in Children - JAMA Network

Cisplatin has been an important component of chemotherapy for cure and control of several pediatric and adult malignant tumors.

Cisplatin-induced nephrotoxicity in children: what is the best ...

Cisplatin continues to play a major role in the treatment of children with cancer. Hydration alone or in combination with mannitol has generally ...

Prevention of cisplatin-induced hearing loss in children - Frontiers

Cisplatin, an essential chemotherapeutic agent for the treatment of solid tumors in children, is a DNA cross-linking agent. Which causes hearing ...

Balancing the Benefit and Toxicity of Cisplatin in Young Children ...

However, although the drug has lifesaving benefits, it also causes some degree of hearing loss in about 60% of children who receive this therapy ...

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

More than half of adult and pediatric patients with cancer treated with cisplatin developed hearing impairment with major impact on patients' ...

The cumulative incidence of cisplatin‐induced hearing loss in young ...

Cisplatin is a highly effective platinum antineoplastic agent used for the treatment of various types of pediatric malignancies, contributing to ...

Long-term cisplatin nephrotoxicity after childhood cancer

This study is to evaluate the prevalence of, and risk factors for, long-term cisplatin nephrotoxicity after treatment for childhood cancer.

Sodium Thiosulfate Reduces Hearing Loss in Kids with Cancer - NCI

“Cisplatin is an effective treatment for cancer, but it causes permanent hearing loss in up to 75% of children who receive it,” said Lisa L.

Renal toxicity and chemotherapy in children with cancer

Even though ifosfamide and cisplatin are the chemotherapy agents most often responsible for kidney damage, the use of other anti-cancer drugs is ...

Cisplatin and Hearing Loss: Until Now, an Unquantified Risk

Cisplatin is one of the most effective chemotherapy agents, used in just under half of pediatric cancer cases. Permanent hearing loss is a ...

Acute Kidney Injury During Cisplatin Infusions in Children Treated ...

Cisplatin, a chemotherapy commonly used to treat pediatric solid tumors (brain tumors, neuroblastoma, hepatoblastoma, and osteosarcoma), is ...

Renal toxicity of cisplatin in children - The Journal of Pediatrics

We measured renal fucntion in 22 children receiving cisplatin as initial treatment for neuroblastoma or malignant germ cell tumors.

Cisplatin pharmacokinetics in children with cancer - ScienceDirect

Cisplatin is an important drug in the treatment of a number of paediatric cancers yet, despite wide-spread use, there are only very limited data on the ...

Cisplatin Toxicity in Children with Malignancy - CoLab

However, cisplatin-based treatments are limited by the risk of severe and progressive toxicities, such as oto- or nephrotoxicity, that can be ...

Late renal toxicity of treatment for childhood malignancy: risk factors ...

There is little information about risk factors for cisplatin nephrotoxicity in children, but high total dose and dose rate, patient age, ...

Cisplatin Ototoxicity in Children - IntechOpen

Cisplatin is a highly effective chemotherapy medicine used in the treatment of many childhood cancers. Like all medications, cisplatin has many side effects ...

Cisplatin Toxicity in Children with Malignancy - OUCI

Platinum' derivates are antineoplastic agents widely adopted for their efficacy for the treatment of many pediatric cancers. The use of cisplatin has ...