Citations to Human liver chimeric mice provide a model for hepatitis ...

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment ... Citation Information: J Clin Invest. 2010;120(3):924-930. https ...

Human liver chimeric mice provide a model for hepatitis B ... - PubMed

This human liver chimeric mouse model will expand the experimental possibilities for studying HBV and HCV infection, and possibly other human hepatotropic ...

Human liver chimeric mice provide a model for hepatitis B and C ...

Here we have shown that a high transplantation dose (3 × 106 to 5 × 106 human hepatocytes/mouse) generates a higher rate of liver chimerism than ...

Human liver chimeric mice provide a model for hepatitis B and C ...

This human liver chimeric mouse model will expand the experimental possibilities for studying HBV and HCV infection, and possibly other human ...

Chimeric mouse model of hepatitis B virus infection - ScienceDirect

(4) While mouse hepatocytes do not support HBV infection, human-chimeric mice can be efficiently infected by injecting infectious serum derived from either ...

Humanized chimeric mouse models of hepatitis B virus infection

First, FRG mice can be engrafted with human hepatocytes at any age and remain healthy for more than half a year. This stable model has been used to test the ...

A Chimeric Humanized Mouse Model by Engrafting the ... - Frontiers

The first line cells used for HBV infection has been the primary human hepatocytes (PHHs). After PHHs were engrafted in the liver of an immune-deficient mouse, ...

Hepatitis C virus replication in mice with chimeric human livers

Lack of a small animal model of the human hepatitis C virus (HCV) has impeded development of antiviral therapies against this epidemic infection.

Mice With Human Livers - Gastroenterology

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment ... In vivo drug metabolism model for human cytochrome P450 enzyme ...

Human liver chimeric mice provide a model for hepatitis B and C ...

Dienstag J.L.. Q1. NEJM Group. New England Journal of Medicine , 2008 , citations by CoLab: 708 | Abstract.

[PDF] Hepatitis C virus replication in mice with chimeric human livers ...

908 Citations · Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus · Human liver chimeric mice provide a model for ...

A first step towards a mouse model for hepatitis C virus infection ...

Results: AFC8-hu HSC/Hep mice supported HCV infection in the liver and generated a human immune T-cell response against HCV. HCV infection induced liver ...

Mice With Human Livers - Gastroenterology

Hepatology 2001;33:981–988. 14. Bissig KD, Wieland SF, Tran P, et al. Human liver chimeric mice provide a model for hepatitis B and C ...

A human liver chimeric mouse model for non-alcoholic fatty liver ...

Within the same chimeric liver, human hepatocytes developed pronounced steatosis while murine hepatocytes remained normal. •. Unbiased ...

Establishment of Humanized Mice for the Study of HBV - Frontiers

Dual Humanized Mouse Models ... Although majority of these immunodeficient human liver chimeric mice have provided valuable insights on virology, ...

[PDF] A humanized mouse model to study hepatitis C virus infection ...

40 References · Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. · Hepatitis C virus replication in mice with ...

Optimized HepaRG is a suitable cell source to generate the human ...

The human liver chimeric mouse with primary human hepatocytes (PHHs) engraftment has been demonstrated to be a useful animal model to study hepatitis B ...

Liver immune‐pathogenesis and therapy of human liver tropic virus ...

We have recently developed the humanized mouse model with both human immune and human liver cells (AFC8-hu HSC/Hep) to study immunopathogenesis ...

Combinatorial RNA Interference Therapy Prevents Selection of Pre ...

Human liver chimeric mice were infected with a mixture of wild-type and T472C HBV, a S1-resistant HBV variant and then treated with a single or ...

Mice with Chimeric Human Livers and Their Applications - OUCI

List of references · Bukh J (2012) Animal models for the study of hepatitis C virus infection and related liver disease. · Wakita T, Kato T (2006) Development of ...