Clinical Implication of Genetic Testing in Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is one of the important causes of heart failure (HF). With the rapidly evolving technologies for gene analysis and tremendous ...

Implications of Genetic Testing in Dilated Cardiomyopathy

Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical phenotypes are common in genetic DCM, but their exact ...

Implications of Genetic Testing in Dilated Cardiomyopathy - PubMed

Background: Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical phenotypes are common in genetic DCM, but their exact contribution ...

Genetics of Dilated Cardiomyopathy: Clinical Implications

A pathogenic gene mutation can be identified in almost 40% of DCM patients. The recent discoveries and future research in the field of genotype- ...

How to… conduct genetic testing for patients with DCM

Prognostic and therapeutic implications: Genetic testing results can influence clinical decision making for DCM patients. Pathogenic variants in ...

Challenges and Applications of Genetic Testing in Dilated ...

Genetic tests for dilated cardiomyopathy (DCM) have a diagnostic yield of up to 40%, but there is significant genetic heterogeneity and other challenges.

Review Clinical and genetic issues in dilated cardiomyopathy

The discovery of genetic cause for some of DCM, otherwise thought to be idiopathic, and the rapid development of more cost-effective molecular genetic testing ...

Genetics of Adult-Onset Dilated Cardiomyopathy

At present, there is no consensus on when genetic testing should be performed for DCM patients. The American College of Medical Genetics and ...

Evidence-Based Assessment of Genes in Dilated Cardiomyopathy

Although clinical DCM genetic testing panels include an average of ~60 genes, when published evidence for genetic DCM was curated, only 19 genes ...

Clinical Implications of the Genetic Architecture of Dilated ...

A clinical framework aids in referring patients for DCM genetic testing and applying results to patient care. Results of genetic testing can ...

The addition of genetic testing and cardiovascular magnetic ...

The addition of genetic testing and CMR findings to routine clinical investigations increased the confidence of clinicians in stratifying the cause of the DCM ( ...

Science Saturday: Mayo researchers streamline genetic testing in ...

"This may have a significant effect on the diagnosis of genetic dilated cardiomyopathy, improving clinical care for these patients and ...

An intervention strategy to improve genetic testing for dilated ...

Despite its clinical implications in screening and therapy, genetic testing in dilated cardiomyopathy (DCM) is underused. This study evaluated ...

The Genetic Evaluation of Dilated Cardiomyopathy - ScienceDirect

Subsequently, these findings have increased adoption of genetic testing in the management of DCM, which has allowed for improved risk stratification and ...

Approaches to Genetic Screening in Cardiomyopathies: Practical ...

Among patients with DCM, genotype-positive status is associated with increased heart failure and arrhythmia outcomes and worse left ventricular reverse ...

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With ...

Although genotyping allows family screening and influences risk-stratification in patients with nonischemic dilated cardiomyopathy (DCM) or ...

Genetic evaluation of cardiomyopathy: a clinical practice resource of ...

Cascade genetic testing of at-risk family members is recommended for pathogenic and likely pathogenic variants. c. In addition to routine ...

HRS/EHRA Expert Consensus Statement on the State of Genetic ...

Genetic testing can be useful for patients with familial DCM to confirm the diagnosis, to recognize those who are at highest risk of arrhythmia and syndromic ...

The Role of Genetics in the Management of Heart Failure Patients

When diagnosing a patient with cardiomyopathy through genetic testing, the scope extends beyond merely identifying the patient's present condition. It ...

Clinical Implication of Genetic Testing in Dilated Cardiomyopathy.

Several genetic variants causing DCM have been identified and this information is used for diagnosis, risk stratification and family screening of DCM patients.