Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms

To address the clinical relevance of small DNA variants in chronic myeloid neoplasms (CMNs), an Association for Molecular Pathology Working Group ...

AMP Addresses Clinical Relevance of DNA Variants in Chronic ...

of high-throughput pan-myeloid sequencing testing panels. The report, “Clinical Significance of DNA Variants in · Chronic Myeloid Neoplasms ...

AMP Clinical Significance of DNA Variants in Chronic Myeloid ...

Title. Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms ; Authoring Organization. Association for Molecular Pathology ; Publication Month/Year.

Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms ...

Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms A Report of the Association for Molecular Pathology ... X Demographics. The data shown below ...

Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms ...

Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms: A Report of the Association for Molecular Pathology. McClure, Rebecca F; Ewalt, Mark D; ...

AMP Addresses Clinical Relevance of DNA Variants in Chronic ...

... myeloid sequencing testing panels. The report, "Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms (CMNs): A Report of the Association for ...

Genetic Testing for Myeloid Neoplasms and Leukemia - Bynder

to clinical significance, and based on clinical studies, the majority of imatinib-resistant variants ... In chronic myeloid leukemia, there ...

Genomic profiling for clinical decision making in myeloid neoplasms ...

Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic cells driven by somatic gene mutations.

chronic myeloid neoplasms - Clinical Lab Products

However, the biological complexity and multiple forms of CMNs have led to variability in the genes included on the test panels that are used to make an accurate ...

AMP publishes report on DNA variants in CMNs - The Hospitalist

A new report addresses the clinical relevance of DNA variants in chronic myeloid neoplasms (CMNs). ... clinical significance of small DNA variants ...

AMP Addresses Clinical Relevance of DNA Variants in Chronic ...

AMP Addresses Clinical Relevance of DNA Variants in Chronic Myeloid Neoplasms · New report recommends minimum of 34 critical gene inclusions for ...

Clinical Validation of a Myeloid Next-Generation Sequencing Panel ...

Our validation set of 77 DNA samples included acute and chronic myeloid neoplasms, with 91 single-nucleotide variants and small insertions/deletions. The 71 RNA ...

A high proportion of germline variants in pediatric chronic myeloid ...

Germline variants were detected in about 60% of pediatric patients with CML, with predominantly hematopoietic genes affected, most frequently ASXL1, NOTCH1, ...

Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms

Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms ... Authors: Rebecca F. McClure; Mark D. Ewalt; Jennifer Crow; Robyn L. Temple-Smolkin; Mrudula ...

Importance of Next-Generation Sequencing in Myeloid Molecular ...

3 With its demonstrated clinical utility in myeloid malignancies, NGS is transforming the testing paradigm and enabling better outcomes for patients.1-3. By ...

Clonal evolution and clinical implications of genetic abnormalities in ...

In the CML-BC samples, mutations were frequently found in the driver genes implicated in myeloid malignancies, including RUNX1, ABL1, ASXL1, ...

(PDF) The Interpretation of Sequence Variants in Myeloid Neoplasms

Conclusions The analysis and interpretation of NGS results in myeloid neoplasia are challenging due to the varied number of detectable gene ...

Myeloid Panel - Cancer Genetics and Genomics Laboratory

All the genes targeted by this assay (see below) are screened for DNA changes (variants). The clinical significance of variants or variant combinations is ...

Impact of additional genetic abnormalities at diagnosis of chronic ...

The BCR::ABL1 gene fusion initiates chronic myeloid leukemia (CML); however, evidence has accumulated from studies of highly selected ...

Designing Myeloid Gene Panels | Archives of Pathology ...

Next-generation sequencing studies are increasingly used in the evaluation of suspected chronic myeloid neoplasms (CMNs), but there is wide ...