Clinical Trials Using Dacarbazine

The clinical trials on this list are studying dacarbazine. All trials on the list are NCI-supported clinical trials, which are sponsored or otherwise ...

Randomized phase III trial of vinblastine, bleomycin, and ... - PubMed

A randomized phase III study was carried out in 57 patients with metastatic melanoma treated with either dacarbazine (DTIC) given intravenously (IV) daily ...

Phase III multicenter randomized trial of the Dartmouth regimen ...

Tumor response was assessable in 226 patients. The response rate to dacarbazine was 10.2% compared with 18.5% for the Dartmouth regimen (P =.09). Bone marrow ...

Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic ...

This multicenter, randomized, international, phase III clinical trial confirms prior experience in smaller trials that documented the efficacy ...

Phase I–II study of plitidepsin and dacarbazine as first-line therapy ...

Results: The overall response rate with plitidepsin/DTIC was 21.4%; all responders had normal serum lactate dehydrogenase (LDH) levels and ...

Nivolumab and Doxorubicin, Vinblastine, and Dacarbazine in Early ...

Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has ...

A randomized, controlled phase III trial of nab-Paclitaxel versus ...

Chemotherapy-naïve patients with stage IV melanoma received nab-paclitaxel 150 mg/m2 on days 1, 8, and 15 every 4 weeks or dacarbazine 1000 mg/m2 every 3 ...

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic ...

Study Design and Treatment ... Treatment was discontinued if toxic effects associated with the drug or progressive disease was noted during weeks ...

A trial of dacarbazine and ipilimumab for stage 3 or 4 melanoma ...

The researchers found that having ipilimumab with dacarbazine increased the length of time people lived after treatment. Doctors call this an improvement in ...

Re-evaluating the role of dacarbazine in metastatic melanoma

The first of these trials demonstrated a 19% response rate in 110 evaluable patients who received dacarbazine in 3-weekly cycles, most often at a dose of 250 mg ...

Phase I clinical trial of the Src inhibitor dasatinib with dacarbazine in ...

Src inhibitors sensitise melanoma cells to chemotherapy in preclinical models. The combination of dasatinib and dacarbazine was tested in a ...

Clinical Trials - Mayo Foundation for Medical Education and Research

This randomized phase II trial studies how well cabozantinib-s-malate works compared with temozolomide or dacarbazine in treating patients with melanoma of the ...

Dacarbazine - NCI

This page contains brief information about dacarbazine and a collection of links to more information about the use of this drug, research results, and ongoing ...

Dacarbazine: Uses, Interactions, Mechanism of Action - DrugBank

Dacarbazine is an antineoplastic agent used to treat malignant melanoma and Hodgkin's disease. Generic Name: Dacarbazine; DrugBank Accession Number: DB00851 ...

Dacarbazine (DTIC) | Cancer information

Dacarbazine is a chemotherapy drug. It is used to treat melanoma, soft tissue sarcoma and Hodgkin lymphoma. Find out how you have it, possible sode effects ...

A Multicenter, Randomized, Double-Blind Study of Dacarbazine ...

A Multicenter, Randomized, Double-Blind Study of Dacarbazine With or Without Genasense in Chemotherapy-naive Subjects with Advanced Melanoma and Low LDH.

Phase III clinical trial of the combination of cisplatin, dacarbazine ...

Patients and Methods: Patients with advanced malignant melanoma were treated with CDDP + DTIC + BCNU (CDB) with or without TAM. ... Results: There were 184 ...

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

In our study, given the magnitude of the clinical benefit observed in patients receiving nivolumab versus those receiving dacarbazine, PD-L1 ...

A Randomized Phase II and Pharmacokinetic Study of Dacarbazine ...

We conducted a randomized phase II study to determine the efficacy of dacarbazine (DTIC) in recurrent gliomas. Patients were randomly assigned to receive ...

Dacarbazine (intravenous route, injection route) - Mayo Clinic

Dacarbazine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be ...