Clinical and genetic issues in familial dilated cardiomyopathy

Idiopathic dilated cardiomyopathy (IDC) is characterized by left ventricular dilatation and systolic dysfunction after known causes have been excluded.

clinical and genetic issues in familial dilated cardiomyopathy

A consensus has emerged that with a new diagnosis of idiopathic dilated cardiomyopathy (IDC), the clinical screening of first-degree family ...

Dilated cardiomyopathy was discovered in 65 subjects from 48 of the 445 families (10.8%) as determined by full cardiac evaluation or at autopsy. Of the 65 ...

Clinical and Genetic Issues in Familial Dilated Cardiomyopathy

Topic(s):. Heart Failure & Cardiomyopathies · View Full Text · PDF.

Review Clinical and genetic issues in dilated cardiomyopathy

Dilated cardiomyopathy (DCM), usually diagnosed as idiopathic dilated cardiomyopathy (IDC), has been shown to have a familial basis in 20–35% of cases.

Clinical and genetic issues in familial dilated cardiomyopathy

Familial dilated cardiomyopathy demonstrates incomplete penetrance, variable expression, and significant locus and allelic heterogeneity, making clinical and ...

Clinical and Genetic Issues in Familial Dilated Cardiomyopathy

Familial dilated cardiomyopathy: cardiac abnormali- ties are common in asymptomatic relatives and may represent early disease. J Am Coll Cardiol 1998;31:195–201 ...

Clinical and Genetic Investigations of 109 Index Patients With ...

The most common presentation is with symptoms of heart failure (HF), although stroke, severe arrhythmias, and sudden cardiac death (SCD) may be ...

Familial dilated cardiomyopathy - Genetics - MedlinePlus

Familial dilated cardiomyopathy is a genetic form of heart disease. It occurs when heart (cardiac) muscle becomes thin and weakened in at least one chamber of ...

Clinical and genetic issues in familial dilated cardiomyopathy

A consensus has emerged that with a new diagnosis of idiopathic dilated cardiomyopathy (IDC), the clinical screening of first-degree family ...

Clinical Implication of Genetic Testing in Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is one of the important causes of heart failure (HF). With the rapidly evolving technologies for gene analysis ...

Complexities of Genetic Testing in Familial Dilated Cardiomyopathy

Among patients who present with unexplained cardiomyopathy, ≈50% are attributed to idiopathic DCM. ... A familial component has been estimated to ...

Clinical and genetic issues in dilated cardiomyopathy: A review for ...

Genetic studies in familial dilated cardiomyopathy (FDC) have shown dramatic locus heterogeneity with mutations identified in >30 mostly autosomal genes showing ...

Familial Dilated Cardiomyopathy - UCSF Cardiology

Familial Dilated Cardiomyopathy. Dilated ... We expect to identify more genes responsible for DCM as our knowledge in cardiac genetics improves over time.

Atlas of the clinical genetics of human dilated cardiomyopathy

Dilated cardiomyopathy (DCM) accounts for 30–40% of all heart failure cases in large clinical trials and is the leading cause of heart transplantation. There is ...

Genetics of dilated cardiomyopathy - UpToDate

INTRODUCTION. Dilated cardiomyopathy (DCM) is a common cause of heart failure (HF) and is the most common diagnosis in patients referred for ...

143 Clinical and Genetic Characteristics of Familial Dilated ...

Background Up to fifty percent of idiopathic dilated cardiomyopathy (DCM) has a familial basis. Variants can occur in over 40 genes, though truncating ...

Genetic Counseling and Screening Issues in Familial Dilated ...

KEY WORDS: dilated cardiomyopathy; genetic counseling; cardiac genetics. INTRODUCTION. Cardiomyopathy (“heart muscle disease”) is a common cause of heart ...

Medline ® Abstracts for References 1-10 of 'Familial dilated ...

BACKGROUND A genetic form of disease transmission has been identified in a relevant proportion of patients with dilated cardiomyopathy (DCM). Variable clinical ...

Challenges and Applications of Genetic Testing in Dilated ...

Genetic tests for dilated cardiomyopathy (DCM) have a diagnostic yield of up to 40%, but there is significant genetic heterogeneity and other challenges.