Clinical trial design in the era of precision medicine

This review focuses on the design, advantages, limitations, and challenges of a spectrum of clinical trial designs in the era of precision oncology.

Clinical trial design in the era of precision medicine - PubMed

This review focuses on the design, advantages, limitations, and challenges of a spectrum of clinical trial designs in the era of precision oncology.

New clinical trial design in precision medicine - Nature

In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from ...

New clinical trial designs in the era of precision medicine - PubMed

The advent of precision medicine in oncology has been accompanied by the introduction of novel clinical trial designs that aim to identify ...

New clinical trial designs in the era of precision medicine

In this article, we give an overview of the different biomarker-based designs, comparing the features of enrichment, randomize-all, umbrella, and basket trials.

New Clinical Trial Designs in the Era of Precision Medicine

How it works: In this type of trial, multiple treatments are tested at the same time, and the study can be “adapted” or changed as we better ...

New clinical trial designs in the era of precision medicine - FEBS Press

New clinical trial designs are helping optimize early drug development. An umbrella trial is a master protocol for which the patient's ...

Precision Medicine and Innovative Clinical Trial Designs - Vial

The application of precision medicine in clinical research has changed the way trials are conducted and created opportunities for matching the right treatment ...

Evolution of the Randomized Clinical Trial in the Era of Precision ...

To fully realize the potential of precision medicine, our community will need to more carefully consider its implications on study design. Our ...

Introduction to Designing Clinical Trials in the Era of Precision ...

James Wason, Professor of Biostatistics at Newcastle University, discusses designing clinical trials in the era of precision medicine, ...

[PDF] New clinical trial designs in the era of precision medicine

Semantic Scholar extracted view of "New clinical trial designs in the era of precision medicine: An overview of definitions, strengths, weaknesses, ...

Basket Trials and the Evolution of Clinical Trial Design in an Era of ...

As clinical trials evolve to integrate precision medicine, it is critical that enthusiasm for genetics does not push the still-valuable ...

Innovative Clinical Trial Designs in the Era of Precision Oncology

Marker x Treatment Interaction Design for assessment of the Clinical. Utility ... used in precision medicine at the right time for the patient. ◇. Role ...

Clinical trial design: Past, present, and future in the context of big ...

In this section, we review new trial concepts and designs that have evolved to accommodate such advances in precision medicine. Adaptive Design.

(PDF) Clinical trial design in the era of precision medicine

Precision medicine uses tumor and cell‐free DNA profiling, immune markers, RNA and proteomic analyses, and other biomarkers in combination with ...

Study designs for clinical trials applied to personalised medicine

New clinical trial designs in the era of precision medicine: an overview of definitions, strengths, weaknesses, and current use in oncology. Cancer Treat ...

Precision Medicine Trials for Cancer: A New Era Begins - NCI

... precision medicine is influencing the design and conduct of NCI-supported clinical trials. Conventional cancer clinical trials have produced ...

New clinical trial designs for establishing drug efficacy and safety in ...

New clinical trial designs for establishing drug efficacy and safety in a precision medicine era. Hiddo J. L. Heerspink PhD,. Corresponding ...

Ethical considerations of neuro-oncology trial design in the era of ...

We review the pertinent ethical considerations for clinical trials of precision medicine in neuro-oncology and discuss methods to protect ...

BIODS 248: Clinical Trial Design in the Age of Precision Medicine ...

BIODS 248: Clinical Trial Design in the Age of Precision Medicine and Health (STATS 248). Traditional designs for Phase I, II ...