Clonal Heterogeneity and Tumor Evolution

Clonal Heterogeneity and Tumor Evolution: Past, Present ... - PubMed

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that ...

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the ...

We review data and technologies that have revealed intra-tumor heterogeneity across cancer types and the dynamics, constraints, and contingencies inherent to ...

Past, Present, and the Future. - ETSU Libraries - Ex Libris Discovery

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future. Check holdings ETSU Quillen College of Medicine Library ETSU Medical Library ...

Biological and Clinical Implications of Clonal Heterogeneity and ...

First hypothesized over two decades ago, clonal heterogeneity and clonal evolution have been confirmed in multiple myeloma (MM), an incurable cancer of plasma ...

Reconstructing tumor clonal heterogeneity and evolutionary ...

Abstract. The heterogeneity of tumor clones drives the selection and evolution of distinct tumor cell populations, resulting in an intricate ...

The Effects of Clonal Heterogeneity on Cancer Immunosurveillance

Intratumor heterogeneity (ITH) is associated with tumor progression in several clinical and experimental settings and contributes to ...

Clonal Evolution Models of Tumor Heterogeneity - ASCO Publications

The major aim of this review is to build a meaningful link between evolutionary concepts and practical applications in cancer medicine.

Intratumoral heterogeneity and clonal evolution in liver cancer - Nature

Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated.

Clonal Heterogeneity and Tumor Evolution: Implications for Cancer ...

One of the fundamental drivers of therapeutic resistance and disease progression is clonal heterogeneity within tumors, which arises from genomic instability, ...

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the ...

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have revealed ...

Subclonal heterogeneity and evolution in breast cancer - Nature

Subclonal heterogeneity and evolution are characteristics of breast cancer that play a fundamental role in tumour development, progression and resistance to ...

Tumor Evolutionary Principles: How Intratumor Heterogeneity ...

As the cancer genome evolves during cancer progression, subclonal events are introduced into a subset of the progeny, termed branched events (Fig. 2A). A clonal ...

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the ...

Abstract. Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer medicine. Here, we review data and technologies that have ...

Clonal Evolution in Cancer - Mission Bio

Clonal Evolution Drives Tumor Heterogeneity ... The path to cancer is often a long process with mutations accruing over years before a cell becomes malignant.

Clonal Heterogeneity and Tumor Evolution - UCL Discovery

We review data and technologies that have revealed intra-tumor heterogeneity across cancer types and the dynamics, constraints, and contingencies inherent to ...

Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

To test the extent to which cancer cell heterogeneity arises from genetic versus epigenetic differences.

Intratumor Heterogeneity: Evolution through Space and Time

In 1976, Peter Nowell proposed the clonal evolution model of cancer and applied evolutionary models to understand tumor growth and treatment failure and the ...

Re-Evaluating Clonal Dominance in Cancer Evolution - ScienceDirect

In this article we review evidence for cancer clonal heterogeneity, evaluating the importance of tumour subclones and their growth through both Darwinian and ...

Intra-tumor heterogeneity: lessons from microbial evolution and ...

Clonal mutations are shared by all cancer cells within the sample and thus are derived from a common ancestor, whereas subclonal mutations have ...

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the ...

This review examines intrapatient cancer heterogeneity and genetic clonal evolution in metastatic CRC, with an emphasis on clinical applications.