Clonal evolution in primary breast cancers under sequential ...

Sequential epirubicin and docetaxel monotherapy caused profound redistribution of smaller subclones in primary breast cancer.

Subclonal evolution during primary breast cancer treatment is largely unexplored. We aimed to assess the dynamic changes in subclonal ...

Clonal Evolution in Breast Cancer Revealed by Single Nucleus ...

Sequencing studies of breast tumor cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumors. Here, ...

(PDF) Clonal evolution in primary breast cancers under sequential ...

Conclusions Sequential epirubicin and docetaxel monotherapy caused profound redistribution of smaller subclones in primary breast cancer, while early truncal ...

Clonal evolution in primary breast cancers under sequential ...

Abstract Background Subclonal evolution during primary breast cancer treatment is largely unexplored. We aimed to assess the dynamic changes in subclonal ...

Subclonal heterogeneity and evolution in breast cancer - Nature

Single-cell sequencing of circulating tumour cells (CTC's) of patients with metastatic breast cancer versus patients with primary breast cancer, ...

Clonal evolution in primary breast cancers under sequential ... - OUCI

Abstract Background Subclonal evolution during primary breast cancer treatment is largely unexplored. We aimed to assess the dynamic changes in subclonal ...

Adaptation and selection shape clonal evolution of tumors during ...

Tumor recurrence after initial treatment is a frequent cause of death in many cancers, including breast cancer, and recurrent tumors are often ...

Multiclonal Invasion in Breast Tumors Identified by ... - Cell Press

These results support a multiclonal invasion model, in which one or more clones escape the ducts and migrate into the adjacent tissues to establish the ...

Article Genomic Evolution of Breast Cancer Metastasis and Relapse

Several lines of analysis indicate that clones seeding metastasis or relapse disseminate late from primary tumors, but continue to acquire ...

The Genetic Landscape and Clonal Evolution of Breast Cancer ...

Longitudinal analysis of samples from patients with estrogen receptor–positive breast cancer identified the mechanisms of resistance and clonal evolution.

Reconstructing tumor clonal heterogeneity and evolutionary ...

While tumor bulk DNA sequencing helps elucidate intratumor heterogeneity, challenges such as the misidentification of mutation multiplicity due ...

Clonal Evolution - an overview | ScienceDirect Topics

The clonal evolution hypothesis is based on the idea that most cancers arise from a single altered cell, and every cell within a tumor is equally likely to be ...

Chemoresistance Evolution in Triple-Negative Breast Cancer ...

In the clonal persistence patients, we applied both single-cell DNA- and RNA-sequencing methods, which further showed that genomic mutations and ...

Circulating Cell-Free DNA Reflects the Clonal Evolution of Breast ...

Blood, serum, and either formalin-fixed paraffin-embedded (FFPE) sections or fresh frozen (FF) tissues from the primary tumor and metastatic sites were ...

ClonEvol: clonal ordering and visualization in cancer sequencing

Reconstruction of clonal evolution is critical for understanding tumor progression and implementing personalized therapies. This is often done by clustering ...

Clonal Evolution in Breast Cancer Revealed by Single Nucleus ...

Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumours.

Mutation Profiling of Key Cancer Genes in Primary Breast Cancers ...

However, primary only mutations were seen as well, indicating clonal divergence within the primary tumor, either with other clones being selected for metastatic ...

Clonal evolution in breast cancer revealed by - ProQuest

Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumours.

The clonal and mutational evolution spectrum of primary triple ...

It is shown that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal ...