Combining evidence from human genetic and functional screens to ...

Genome-wide common variant and exome-wide rare variant analyses can provide complementary lines of evidence to nominate genes associated with ...

We highlight therapeutic avenues for altering obesity and body fat distribution by modulating lipid accumulation.

Combining evidence from human genetic and functional screens to ...

Overall adiposity and body fat distribution are heritable traits associated with altered risk of cardiometabolic disease and mortality.

Combining evidence from human genetic and functional screens to ...

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution · Baya NA., Sur Erdem I.

Combining evidence from human genetic and functional screens to ...

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution

medRxiv on X: "Combining evidence from human genetic and ...

Combining evidence from human genetic and functional screens to identify pathways altering obesity... Overall adiposity and body fat ...

Combining evidence from human genetic and functional screens to ...

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution. Nikolas Baya. ,. Ilknur Sur Erdem.

Publications - Center for Genomic Medicine

This longitudinal cohort study aims to advance research by providing a rich resource of genetic and phenotypic information, enabling powerful ...

In vivo CRISPR screens identify a dual function of MEN1 in ... - Nature

Functional genomic screens in two-dimensional cell culture models are limited in identifying therapeutic targets that influence the tumor ...

Impact of Genomic Variation on Function (IGVF) Consortium

The program is based on recommendations from the 2019 workshop "From Genome to Phenotype: Genomic Variation Identification, Association, and Function in Human ...

Annual Review of Genomics and Human Genetics - Current Issue

AIMS AND SCOPE OF JOURNAL: The Annual Review of Genomics and Human Genetics covers significant developments in the field of genomics as they apply to human ...

High-content CRISPR screening | Nature Reviews Methods Primers

Genetic screening provides a powerful approach for identifying genes, pathways and mechanisms involved in a given phenotype or biological ...

From GWAS to Function: Using Functional Genomics to Identify the ...

Genome-wide association studies (GWAS) are designed to map the polygenic architecture of common diseases by identifying genetic variants present ...

Combined bioinformatic and splicing analysis of likely benign ...

Identifying variants in clinically relevant genes that affect splicing is challenging yet essential for accurate genetic diagnosis for many diseases. Current ...

George Hindy's research works | Regeneron and other places

We prioritized 220 candidate causal genes, combining ... Combining evidence from human genetic and functional screens to identify pathways altering obesity and ...

Genetic screens and functional genomics using CRISPR/Cas9 ...

Functional genomics attempts to understand the genome by perturbing the flow of information from DNA to RNA to protein, in order to learn ...

Translational relevance of forward genetic screens in animal models ...

Next generation sequencing facilitates identification of candidate mutations. •. Combining human and animal studies reveals the biology of human psychiatric ...

Genes and genetics explained - Better Health Channel

The letter sequence of each gene contains information on building specific molecules (such as proteins or hormones – both essential to the growth and ...

Genetic interaction screens advance in reverse - Genes Dev

Inter- estingly, the results added to a growing and intriguing body of evidence supporting the idea that many pairs of duplicated ribosomal protein genes ...

Genome-wide functional screen of 3′UTR variants uncovers causal ...

We applied MPRAu to six human cell lines, focusing on genetic variants associated with genome-wide association studies (GWAS) and human evolutionary adaptation.