Common Genetic Determinants of Intraocular Pressure and ...

Common genetic determinants of intraocular pressure and primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy.

Common Genetic Determinants of Intraocular Pressure and Primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma ...

Common Genetic Determinants of Intraocular Pressure and ... - PLOS

Expression studies · GAS7 is located in a chromosomal region previously identified by a linkage study of glaucoma · The second variant that we found to be ...

Common Genetic Determinants of Intraocular Pressure and Primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy.

Common genetic determinants of intraocular pressure and primary ...

Common genetic determinants of intraocular pressure and primary open-angle glaucoma. van Koolwijk, LM; Ramdas, WD; Ikram, MK; Jansonius, NM; Pasutto, F ...

Common genetic determinants of intraocular pressure and primary ...

Intraocular pressure (IOP) is a highly heritable risk factor for primary open-angle glaucoma and is the only target for current glaucoma therapy. The genetic ...

[PDF] Common Genetic Determinants of Intraocular Pressure and ...

GAS7 and TMCO1 are highly expressed in the ciliary body and trabecular meshwork as well as in the lamina cribrosa, optic nerve, and retina, and both genes ...

Common Genetic Determinants of Intraocular Pressure and Primary ...

Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma. PLoS Genetics (print), 8(5). https://doi.org/10.1371/journal.pgen.1002611.

A large multi-ethnic genome-wide association study identifies novel ...

Our report of 40 novel loci associated with IOP substantially increased the proportion of variance in IOP explained by specific genetic factors.

Common genetic determinants of intraocular pressure and primary ...

Common genetic determinants of intraocular pressure and primary open-angle glaucoma. Leonieke M E van Koolwijk, Wishal D Ramdas, M Kamran Ikram, Nomdo M ...

Common genetic determinants of intraocular pressure and primary ...

Common genetic determinants of intraocular pressure and primary open-angle Glaucoma. PLoS Genetics, 8(5), 14pp. https://doi.org/10.1371/journal.pgen.1002611.

Common Genetic Determinants of Intraocular Pressure and Primary ...

List of references · S Monemi, Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22. · T Rezaie, Adult-onset primary open-angle ...

Genetic Determinants of Intraocular Pressure | Request PDF

Intraocular pressure (IOP) is the cardinal and only modifiable risk factor for glaucoma, the leading cause of irreparable blindness worldwide.

Towards modifying the genetic predisposition for glaucoma: An ...

Well-established non-modifiable risk factors for POAG include older age, non-White ethnicity, and family history of glaucoma (Stein et al., 2021) – with the ...

Primary open angle glaucoma genetics: The common variants and ...

The well recognised risk factors for POAG include higher age, high IOP, decreased central corneal thickness (CCT), African descent, high myopia ...

Genome-wide analysis identified 17 new loci influencing intraocular ...

Intraocular pressure (IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights ...

10 Years of GWAS in intraocular pressure - Frontiers

Since then, numerous common genetic variants associated with IOP have been discovered (Hysi et al., 2014; Springelkamp et al., 2014; Choquet et ...

Replication of a Glaucoma Candidate Gene on 5q22.1 for ... - IOVS

Elevated intraocular pressure (IOP) causes glaucomatous optic nerve damage, especially in the primary open-angle glaucoma (POAG) subtype. As most previous ...

Common Genetic Determinants of Intraocular Pressure and Primary ...

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Genes, pathways, and animal models in primary open-angle ...

The known risk factors for POAG include a higher age, African ancestry, high intraocular pressure (IOP), decreased central corneal thickness ( ...