Comprehensive LncRNA and Potential Molecular Mechanism ...

In this study, comprehensive bioinformatics analysis identified lncRNAs with altered expression in three major autoimmune diseases that may combine with ...

Comprehensive analysis of long noncoding RNA (lncRNA)

Despite intensive efforts to decipher lncRNA functions (9–12), understanding the detailed molecular mechanisms how lncRNAs elicit their functions remains, ...

(PDF) Comprehensive LncRNA and Potential Molecular Mechanism ...

These RNAs were involved in the mitogen-activated protein kinase signaling pathway and inflammatory cytokine pathways. Conclusions: In this study, comprehensive ...

Long non-coding RNAs: definitions, functions, challenges and ...

We address lncRNA definition, nomenclature, conservation, expression, phenotypic visibility, functional assays and molecular mechanisms ...

Molecular mechanisms of long noncoding RNAs and their role in ...

LncRNAs are long non-coding regulatory RNAs that are longer than 200 nucleotides. One of the major functions of lncRNAs is the regulation of specific gene ...

Molecular Mechanisms of Long Noncoding RNAs - ScienceDirect.com

These archetypes of lncRNA function may be a useful framework to consider how lncRNAs acquire properties as biological signal transducers and ...

Gene regulation by long non-coding RNAs and its biological functions

... lncRNAs are potential biomarkers and provide a rationale to target them clinically. In this Review, we discuss the mechanisms of lncRNA ...

The mechanisms and diagnostic potential of lncRNAs, miRNAs, and ...

lncRNAs and microRNAs (miRNAs) belong to the class of ncRNAs, which can interfere with tumorigenesis, tumor invasion, and metastasis by regulating epigenetic, ...

TransLnc: a comprehensive resource for translatable lncRNAs ...

Long non-coding RNAs (lncRNAs) have recently been demonstrated as an abundant class of RNA molecules that play important roles in various types ...

Long non-coding RNAs: roles in cellular stress responses and ...

Additionally, lncRNA plays important roles in epigenetic mechanisms operating at chromatin and in maintaining chromatin architecture. Here, we address three ...

The emerging potentials of lncRNA DRAIC in human cancers

Functional assays have revealed a series of molecular mechanisms of lncRNA DRAIC in the development of diseases. These features can be exploited ...

Comprehensive analysis of lncRNA-mRNAs co-expression network ...

The aim of this study is to identify cSCC-specific lncRNAs and indicated that six unstudied lncRNAs may serve an important role in endoplasmic reticulum stress ...

Molecular Mechanisms of lncRNAs in the Dependent Regulation of ...

Deep whole genome and transcriptome sequencing have highlighted the importance of an emerging class of non-coding RNA longer than 200 nucleotides (i.e., ...

The Function and Therapeutic Potential of Long Non-coding RNAs ...

lncRNAs are a heterogeneous group of transcripts exerting major regulatory roles in gene expression, and their importance in cardiovascular disease has been ...

lncRNAfunc: a knowledgebase of lncRNA function in human cancer

Our intensive studies of lncRNAs provide diverse potential mechanisms of lncRNAs that regulate gene expression through binding enhancers and ...

Computational Methods and Applications for Identifying Disease ...

Identification of disease-associated lncRNAs is becoming increasingly crucial for fundamentally improving our understanding of molecular ...

lncRNAs: potential therapeutic targets and biomarkers for pancreatic ...

The mechanism of action of a lncRNA is highly dependent on its subcellular localization ( Figure 1 ). Although it is not clear what fraction of the currently ...

Construction and integrated analysis of a lncRNA-associated ...

Background: Long noncoding RNAs (lncRNAs) can serve as a competing endogenous RNA (ceRNA) in regulating gene expression in multiple cancers by sponging miRNA.

Comprehensive LncRNA and Potential Molecular Mechanism ...

Comprehensive LncRNA and Potential Molecular Mechanism Analysis in Noninfectious Uveitis. https://doi.org/10.1167/tvst.12.3.2 ·. Journal: Translational Vision ...

The multidimensional mechanisms of long noncoding RNA function

The efforts to generate a comprehensive atlas of the transcripts expressed in cells have revealed an extremely large collection of lncRNAs [1, 2] ...