Computational analysis of the functional impact of MHC|II ...

Computational analysis of the functional impact of MHC-II ... - Frontiers

The tumor microenvironment (TME) plays a crucial role in tumor progression and immunoregulation. Major histocompatibility complex class II (MHC-II) is ...

Computational and Experimental Approaches to Reveal the Effects ...

The first study on the functional consequences of human MECP2 mutations causing Rett syndrome was reported only one year after the SNP screening results [197].

MHC-II dynamics are maintained in HLA-DR allotypes to ... - Nature

... functional effect with regard to self-peptide presentation. MHC-II allotypes with the ability to present certain self-peptides are ...

A comparison on predicting functional impact of genomic variants

A review study: computational techniques for expecting the impact of non-synonymous single nucleotide variants in human diseases. Gene. 2019 ...

Dietary suppression of MHC class II expression in intestinal ...

First, we assayed the functional potential of MHC-II+ and MHC-II ... Computational analysis of scRNA-seq. We profiled Lgr5-high ISCs ...

Causal ALS genes impact the MHC class II antigen ... - PNAS

These pathways include protein homeostasis, gene expression, mitochondrial function, intracellular transport, endoplasmic reticulum stress, RNA ...

Computational Tools to Assess the Functional Consequences of ...

... (ii) physicochemical ... computational methods for the functional interpretation of pharmacogenetic variability across variant classes.

Tuning DO:DM Ratios Modulates MHC Class II Immunopeptidomes

... impact of DO:DM on MHC-II peptidomic landscapes. We used a series of ... Collectively, this knockdown study demonstrates that a major function of DO ...

Major Histocompatibility Complex (MHC) Class I and ... - Frontiers

In other cases, the functional impact of disease-associated polymorphisms ... Computational studies on MHC class I and II dynamics. Finally, it has to ...

Predicting HLA class II antigen presentation through integrated deep ...

Our HLA-II gene expression analysis in the Cancer Genomic Atlas ... NetMHCstab—predicting stability of peptide–MHC-I complexes; impacts for ...

Characterization of the major histocompatibility complex class II ...

Therefore, diminished binding function is an effect of amino acid substitution or fragment deletion and not a consequence of reduced surface expression. Figure ...

Computational analysis of the functional and structural impact of the ...

Several mutations in human PC are associated with decreased protein production or altered protein structure, resulting in PC deficiency. In this ...

Evolving Insights for MHC Class II Antigen Processing and ...

Impact of MHC Class II Polymorphisms on Peptide ... Improvements in biophysical methods and computational resources facilitating analysis ...

Analyzing the functional effects of DNA variants with gene editing

... II trials had strong genetic evidence, compared to 43% of failed projects. ... interpretation and building computational models of variant effect.

Functional implications of Major Histocompatibility (MH) variation ...

In particular, the study of MHC class II genes in wild vertebrate populations (from fish to mammals) has provided valuable insight into local adaptation, ...

Major Histocompatibility Complex (MHC) Genes and Disease ...

The later elucidation of the function of MHC molecules in peptide antigen presentation to T cells [9], and the effects of MHC polymorphism on that peptide ...

tappAS: a comprehensive computational framework for the analysis ...

tappAS: a comprehensive computational framework for the analysis of the functional impact of differential splicing ... Module II can be ...

A Genome-wide Multidimensional RNAi Screen Reveals Pathways ...

(D) Functional annotation of the candidate genes involved in the various effects on MHC-II antigen presentation. Annotation retrieved from ...

The MHC locus and genetic susceptibility to autoimmune and ...

... MHC offers an alternative approach to interrogate functional MHC ... In addition, analysis of non-additive effects in MHC-associated loci ...

In-silico analysis unravels the structural and functional ...

Structural and functional effects of deleterious SNPs on the IL-10 protein were screened by various computational tools. A graphical ...