Conquering chemoresistance in pancreatic cancer

Conquering chemoresistance in pancreatic cancer: Exploring novel ...

Targeted therapy focuses on administering drugs that specifically target pathways associated with desmoplasia hypoxia in pancreatic cells, which ...

Conquering chemoresistance in pancreatic cancer: Exploring novel ...

Pancreatic cancer poses a significant challenge within the field of oncology due to its aggressive behaviour, limited treatment choices, ...

Overcoming Drug Resistance in Pancreatic Cancer - PubMed Central

Drug resistance is a key factor that limits the choice of therapies and significantly decreases the efficacy of any chemotherapy drugs for pancreatic cancer.

Reversing chemotherapy resistance in pancreatic cancer

Pancreatic cancer is a particularly aggressive and difficult-to-treat cancer, in part because it is often resistant to chemotherapy.

Chemoresistance in pancreatic ductal adenocarcinoma

The main methods to suppress the EMT pathway to overcome chemoresistance are targeting mesenchymal tumor cells, preventing EMT induction, and increasing EMT.

Overcoming chemotherapy resistance in pancreatic cancer

Researchers have discovered that pancreatic cancer's resistance to chemotherapy is related to the physical stiffness of the extracellular ...

Pancreatic cancer: understanding and overcoming chemoresistance

Pancreatic cancer is a highly aggressive malignancy, which is partly attributable to drug resistance. This Review summarizes the current ...

Conquering Bacterial-Induced Chemoresistance in Pancreatic Cancer

Breaking Down Barriers: Conquering Bacterial-Induced Chemoresistance in Pancreatic Cancer. The Dutch Cancer Society (KWF Kankerbestrijding) has ...

Overcoming chemoresistance by targeting reprogrammed metabolism

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death due to its late diagnosis that removes the ...

Chemoresistance in Pancreatic Cancer - MDPI

Chemoresistance is multifactorial as a result of the interaction among pancreatic cancer cells, cancer stem cells, and the tumor microenvironment. Nevertheless, ...

role of the bitter taste receptor T2R10 - Journal of Cancer

Therefore, chemotherapy often remains the last treatment option [2]. However, its effectiveness is limited because pancreatic cancer exhibits numerous ...

Conquering chemoresistance in pancreatic cancer: Exploring novel ...

Request PDF | On Mar 5, 2024, Pavan Kumar Chintamaneni and others published Conquering chemoresistance in pancreatic cancer: Exploring novel drug therapies ...

Pancreatic Cancer Chemoresistance to Gemcitabine - MDPI

Development of tumor resistance to gemcitabine critically limits the efficacy of this cornerstone of pancreatic cancer chemotherapy. Chemoresistance can be ...

Chemo Boosts KRAS Inhibitor Against Pancreatic Cancer - NCI

Two new studies in mice show that adding chemotherapy to an experimental KRAS inhibitor called MRTX1133 greatly reduced tumor growth and spread ...

Desensitization of NFκB for Overcoming Chemoresistance of ...

Moreover, pancreatic cancer is one of the most intrinsically drug-resistant tumors, and resistance to chemotherapeutic agents is a major cause of treatment ...

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using ...

The combination of gemcitabine and DT2216 synergistically induced cell death in multiple pancreatic cancer cell lines in vitro. In vivo, the combination ...

Overcoming acquired chemo-resistance to gemcitabine

Potentiation of chemotherapeutic agent is urgently needed in almost all stages of pancreatic cancer. Further efforts must be paid on overcoming chemo-resistance ...

Epithelial-mesenchymal transition as a therapeutic target for ...

Indeed, EMT has been shown to contribute to drug resistance in pancreatic cancer. For instance, in a recent study, the patterns of sensitivity and resistance to ...

Gemcitabine resistance of pancreatic cancer cells is mediated by ...

Chemoresistance in pancreatic cancer cells may be caused by the expansion of inherently resistant cancer cells or by the adaptive plasticity ...

Exploring the Therapeutic Potential of Focal Adhesion Kinase ...

... Overcoming Chemoresistance in Pancreatic Ductal Adenocarcinoma. Fabio Scianò1 ... overcoming drug resistance in spheroid models of primary human pancreatic cancer ...