Control of epidermal growth factor receptor endocytosis by receptor ...

Control of epidermal growth factor receptor endocytosis ... - PubMed

Given that ligand binding is essential for the rapid internalization of epidermal growth factor receptor (EGFR), the events induced by ligand binding ...

EGF-induced EGFR dimerization and internalization. As the only well-defined event between ligand binding and kinase activation is receptor dimerization, our ...

Regulation of Epidermal Growth Factor Receptor Signaling by ...

Ligand activation of the epidermal growth factor receptor (EGFR) leads to its rapid internalization and eventual delivery to lysosomes.

Endocytosis of Functional Epidermal Growth Factor Receptor-Green ...

Receptor down-regulation and internalization occur at rates similar to those in cells expressing wild-type EGFR. Western blot analysis reveals that lysosomal ...

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

Endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific ...

Stress-induced endocytosis and degradation of epidermal growth ...

Endocytosis and degradation of epidermal growth factor receptor (EGFR) are two key steps for down-regulation of cell surface level of EGFR and ...

Regulation of epidermal growth factor receptor signalling by ...

The epidermal growth factor receptor (EGFR) is the founding member of the ErbB receptor tyrosine kinase (RTK) family. EGFR signalling controls ...

Multiple mechanisms collectively regulate clathrin-mediated ...

Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR signaling. However, EGFR endocytosis ...

Spatial Regulation of Epidermal Growth Factor Receptor Signaling ...

Here, how the endocytic pathway regulates receptor signaling is discussed, using the epidermal growth factor receptor (EGFR) as a model. In particular, the ...

Control of cell metabolism by the epidermal growth factor receptor

The epidermal growth factor receptor (EGFR) triggers the activation of many intracellular signals that control cell proliferation, growth, survival, ...

Selective regulation of clathrin-mediated epidermal growth factor ...

In addition, epidermal growth factor receptor (EGFR) signaling is regulated by its accumulation within CCPs. Given the diversity of proteins ...

A Novel Endocytic Mechanism of Epidermal Growth Factor Receptor ...

These findings have broad implications toward our understanding of how receptor-mediated processes may affect receptor down-regulation, cell ...

Dual clathrin and integrin signaling systems regulate growth factor ...

Epidermal growth factor receptor (EGFR) is one of the most widely studied members of the RTK superfamily and regulates epithelial tissue ...

Epidermal Growth Factor and Membrane Trafficking: Egf Receptor ...

Activated epidermal growth factor receptors recruit various intracellular proteins leading to signal generation and endocytic trafficking.

Epidermal growth factor receptor and cancer: control of oncogenic ...

Although proteasomal targeting of ErbB proteins has been described, lysosomal degradation upon ligand-induced endocytosis seems to play the ...

Novel mechanism for regulation of epidermal growth factor receptor ...

Furthermore, PKA inhibition may contribute to ligand-induced EGFR endocytosis because epidermal growth factor inhibited 26% of PKA basal activity. On the other ...

Regulation of Epidermal Growth Factor Receptor Signaling by ...

A pervasive role in EGFR regulation is played by endocytosis. Owing to its capacity to instruct degradation of activated EGFRs and reduce receptor expression ...

Regulation of Epidermal Growth Factor Receptor Signaling ... - OUCI

Ligand activation of the epidermal growth factor receptor (EGFR) leads to its rapid internalization and eventual delivery to lysosomes.

(PDF) Regulation of Epidermal Growth Factor Receptor Signaling by ...

We found that after internalization, EGFR remained active in the early endosomes. However, receptors were inactivated before degradation, apparently due to ...

EGF Receptor Control Cell Extracts #5634 - Cell Signaling Technology

The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor ...