Control of iron homeostasis as a key component of macrophage ...

In particular, iron management emerges as a metabolic signature of macrophage activation, with M1 cells committed to reduce iron availability to the ...

Control of iron homeostasis as a key component of macrophage polarization.

Control of iron homeostasis as a key component of macrophage ...

Control of iron homeostasis as a key component of macrophage polarization-article.

Regulation of tissue iron homeostasis: the macrophage “ferrostat”

It is well appreciated that macrophages are vital for systemic iron homeostasis, supplying or sequestering iron as needed for erythropoiesis or ...

Ironing Out the Details: How Iron Orchestrates Macrophage ...

Mechanistically, iron orchestrates macrophage polarization through several aspects, including cellular signaling, cellular metabolism, and epigenetic regulation ...

Macrophage iron homeostasis and polarization in the context of ...

In contrast, iron release from macrophages contributes to bystander cell proliferation, which is important for tissue regeneration and repair. This dichotomy is ...

“Pumping iron”—how macrophages handle iron at the systemic ...

Given its essential role in metabolism and cellular processes such as mitochondrial respiration, an efficient and tightly controlled pathway for ...

Macrophages and Iron Metabolism: Immunity - Cell Press

These biological properties demand that iron metabolism is tightly regulated such that iron is available for core biological functions while ...

Macrophages and Systemic Iron Homeostasis - Karger Publishers

The macrophage is a key agent in iron homeostasis as well as in inflammatory hypoferremia. Unlike other cell types which take up iron ...

The versatile biochemistry of iron in macrophage effector functions

I show how iron, as part of haem or Fe-S clusters, participates in the cellular control of redox homeostasis during pro-inflammatory macrophage ...

Iron Regulation: Macrophages in Control - MDPI

This review focuses on the role of the distinct macrophage populations that contribute to efficient iron metabolism and highlight important cellular and ...

Iron scavenging and myeloid cell polarization: Trends in Immunology

Iron plays an important role in myeloid cell polarization by altering cellular signaling and metabolism, while also affecting chromatin ...

Systemic and cellular consequences of macrophage control of iron ...

Accordingly, macrophages exploit the denial of iron from microbial pathogens as an important strategy to accomplish their key role in innate immunity and host ...

Regulation of tissue iron homeostasis: the macrophage “ferrostat”

( 2 ) Local tissue-resident Mɸs are recruited to the injured site. Since injured cells are more susceptible to iron-induced oxidative damage, ...

EDITORIALS & PERSPECTIVES - Haematologica

Control of iron homeostasis as a key component of macrophage polarization. Cairo Gaetano,1 Locati Massimo,2,3 Mantovani Alberto2,3. 1Department of Human ...

Macrophages and Iron Metabolism | Microbiology Spectrum

By recycling and storing iron from senescent erythrocytes and other damaged cells, the macrophage controls iron homeostasis, supplying most of the iron needed ...

The Iron Curtain: Macrophages at the Interface of Systemic and ...

Thus, iron metabolism is implicated in osteoclasts, bone macrophages that drive bone reabsorption and bone healing. Lastly, most cells and tissues participate ...

Macrophages and Iron: A Special Relationship - MDPI

However, the major targets of homeostatic phagocytosis by macrophages are old/damaged red blood cells. As such, macrophages play a crucial role in iron ...

Differential regulation of iron homeostasis during human ...

Macrophages play a critical role in body iron homeostasis by recovering iron from old red blood cells and returning it to the circulation ...

Polarization dictates iron handling by inflammatory and alternatively ...

2 Macrophages are also important in the maintenance of tissue homeostasis and in the resolution of inflammation. These functions are achieved ...