- Crystal structure of dihydropyrimidine dehydrogenase🔍
- Crystal Structure of the Productive Ternary Complex of ...🔍
- Dihydropyrimidine Dehydrogenase🔍
- Crystal structure of dihydropyrimidinase in complex with anticancer ...🔍
- Rare Dihydropyrimidine Dehydrogenase Variants and Toxicity by ...🔍
- Perturbing the Movement of Hydrogens to Delineate and Assign ...🔍
- Localization of the point mutation sites in the DPD crystal structure🔍
- A ferredoxin|dependent dihydropyrimidine dehydrogenase in ...🔍
Crystal structure of dihydropyrimidine dehydrogenase
Crystal structure of dihydropyrimidine dehydrogenase, a major ...
Dihydropyrimidine dehydrogenase catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding ...
1GTE: DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) FROM ...
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition ...
Crystal structure of dihydropyrimidine dehydrogenase, a major ...
Dihydropyrimidine dehydrogenase catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to ...
Crystal Structure of the Productive Ternary Complex of ...
Crystal Structure of the Productive Ternary Complex of Dihydropyrimidine Dehydrogenase with NADPH and 5-Iodouracil IMPLICATIONS FOR MECHANISM OF INHIBITION ...
Crystal structure of dihydropyrimidine dehydrogenase, a major ...
Dihydropyrimidine dehydrogenase contains two FAD, two FMN and eight [4Fe–4S] clusters, arranged in two electron transfer chains that pass the dimer interface ...
Dihydropyrimidine Dehydrogenase - an overview - ScienceDirect.com
The crystal structure shows that each monomer contains five domains: an N-terminal Fe–S cluster domain, an FAD-binding domain, an NADPH-binding domain, an FMN/ ...
Crystal structure of dihydropyrimidinase in complex with anticancer ...
DHPase [[19], [20], [21], [22], [23]] contains the binuclear metal center that consists of four His, one Asp and one post-translational carbamylated Lys (Kcx) ...
Rare Dihydropyrimidine Dehydrogenase Variants and Toxicity by ...
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil. EMBO J. (2001) 20 ...
Perturbing the Movement of Hydrogens to Delineate and Assign ...
Crystal structure of the activated form of the DPD C671A variant DPD ... chemical sequences of mammalian dihydropyrimidine dehydrogenase ...
Localization of the point mutation sites in the DPD crystal structure
... the inactivation of the human enzyme caused by these point mutations can be inter- preted in a three-dimensional framework provided by the crystal structure ...
Crystal structure of dihydropyrimidine dehydrogenase, a major ...
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti‐cancer drug 5‐fluorouracil. Authors. Doreen ...
A ferredoxin-dependent dihydropyrimidine dehydrogenase in ...
Dihydropyrimidine dehydrogenase (PydA) catalyzes the first step of the reductive pyrimidine degradation (Pyd) pathway in bacteria and eukaryotes, ...
DPYD gene: MedlinePlus Genetics
Dihydropyrimidine dehydrogenase is involved in the first step of the breakdown of pyrimidines. This enzyme converts uracil to another molecule ...
Crystal structure of the productive ternary complex of ... - Sigma-Aldrich
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition ...
Crystal structure of dihydropyrimidine dehydrogenase, a major ...
Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil Check holdings ...
Detailed analysis of five mutations in dihydropyrimidine ...
85T>C (C29R) and the silent mutation c.1896T>C were found in the coding area of DPYD. Crystal structure analysis of DPD protein. To further ...
Novel disease-causing mutations in the dihydropyrimidine ...
... dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure ... Analysis of the crystal structure of pig DPD ...
Dihydropyrimidine dehydrogenase (NADP+) - Wikipedia
In humans the enzyme is encoded by the DPYD gene. ... It is the initial and rate-limiting step in pyrimidine catabolism. ... It catalyzes the reduction of uracil ...
Crystal structure of dihydropyrimidine dehydrogenase, a ... - X-MOL
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Structural Organization of the Human Dihydropyrimidine ...
molecular defects (point mutations, deletions due to exon skipping) that were suggested as a potential molecular basis for DPD deficiency, even.