Current progress in non|Edg family LPA receptor research

Current progress in non-Edg family LPA receptor research - PubMed

Lysophosphatidic acid (LPA) is the simplest phospholipid yet possesses myriad biological functions. Until 2003, the functions of LPA were ...

Current progress in non-Edg family LPA receptor research

Analyses of these non-Edg family LPA receptors have begun to fill in gaps to understand biological functions of LPA such as platelet aggregation and vascular ...

Current progress in non-Edg family LPA receptor research

Here we review recent progress in the non-Edg family LPA receptor research, with special emphasis on the pharmacology, signaling, and physiological roles of ...

Current progress in non-Edg family LPA receptor research.

Semantic Scholar extracted view of "Current progress in non-Edg family LPA receptor research." by K. Yanagida et al.

Non-Edg family LPA receptors: the cutting edge of LPA research

These 'non-Edg family' LPA receptors now provide a new framework for understanding the diverse functions of LPA, including vascular development, platelet ...

Current progress in non-Edg family LPA receptor research - OUCI

Choi, LPA receptors: subtypes and biological actions, Annu. · Sano, Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and ...

LPA receptor signaling: pharmacology, physiology, and ...

LPA2 couples to the Gi/o, Gq/11, and G12/13 family of heterotrimeric G proteins, similar to LPA1 (Fig. 1). These G proteins initiate downstream signaling ...

Non-Edg family lysophosphatidic acid (LPA) receptors | Scholars ...

These findings made us aware of the existence of a novel “non-Edg” LPA receptor family. ... Current progress in non-Edg family LPA receptor research. Authors.

Lysophosphatidic Acid Receptors: Biochemical and Clinical ...

LPA1-3 receptor belongs to the endothelium differentiation gene (EDG) receptor, which has 50-57% amino acid identity with each other, while LPA4-6 receptor, ...

Lysophosphatidic Acid Receptor 4 Activation Augments Drug ...

Here, we show that lysophosphatidic acid (LPA) enhances blood flow by promoting fine vascular networks, thereby improving vascular permeability ...

G-Protein-Coupled Lysophosphatidic Acid Receptors and Their ...

LPA may potentially have a large impact on this important pathway, and thereby on cancer and several other diseases. LPA is widely present in almost all types ...

The lysophosphatidic acid receptor LPA 4 regulates hematopoiesis ...

Consistently, LPA4-deficient BM stromal cells showed downregulated mRNA expression of stem cell factor and tenascin-c in vitro. Taken together, ...

Lysophosphatidic acid–induced YAP/TAZ activation promotes ... - JCI

Yanagida K, Kurikawa Y, Shimizu T, Ishii S. Current progress in non-Edg family LPA receptor research. Biochim Biophys Acta. 2013;1831(1):33–41. View this ...

Lysophosphatidic acid receptors LPA4 and LPA6 differentially ...

Although we previously reported that LPA1 is expressed in HEV ECs (10), that observation was not confirmed in the present study, possibly ...

Structural insights into ligand recognition by the lysophosphatidic ...

Similar Articles · Non-Edg family LPA receptors: the cutting edge of LPA research. · Toward the three-dimensional structure and lysophosphatidic acid binding ...

Role of LPAR3, PKC and EGFR in LPA-induced cell migration in ...

LPA stimulated cell migration in the two oral carcinoma cell lines E10 and SCC-9, but was slightly inhibitory in D2. The receptor expression ...

Non-Edg family LPA receptors: The cutting edge of LPA research

Request PDF | Non-Edg family LPA receptors: The cutting edge of LPA research | Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse ...

Autotaxin facilitates selective LPA receptor signaling - Cell Press

ATX/LPA promotes several (patho)physiological processes, including in pulmonary fibrosis, thus serving as an attractive drug target. However, it ...

Lysophosphatidic Acid (LPA) Induces Plasma Exudation ... - J-Stage

Current progress in non-Edg family LPA receptor research. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2013, Vol.1831, No.1 ...

Role of LPA 4 /p2y9/GPR23 in Negative Regulation of Cell Motility

The LPA1–3 receptors are members of the endothelial cell differentiation gene (Edg) family. LPA4/p2y9/GPR23, a member of the purinergic receptor family, and ...