Cyclin D1 activation in B|cell malignancy

Cyclin D1 activation in B-cell malignancy - PubMed

Cyclin D1 expression is deregulated by chromosome translocation in mantle cell lymphoma and a subset of multiple myeloma. The molecular mechanisms involved ...

Cyclin D1 activation in B-cell malignancy - ASH Publications

The activation of the cyclin D1 gene that occurs in MCL and a subset of MM was used as a model system to investigate the mechanisms responsible for long- ...

Cyclin D1 activation in B-cell malignancy: association with changes ...

Cyclin D1 expression is deregulated by chromosome translocation in mantle cell lymphoma and a subset of multiple myeloma. The molecular mechanisms involved ...

Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control ...

Dysregulation of Cyclin D1 transcription, accumulation and ubiquitination, as well as assembly and hyperactivation of its cognate CDK, lead to ...

Cyclin D1 activation in B-cell malignancy: association with changes ...

Gene Expression. Cyclin D1 activation in B-cell malignancy: association with changes in histone acetylation, DNA methylation, and RNA polymerase ...

The regulation of cyclin D1 degradation: roles in cancer ...

Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of ...

Degradation strategy of cyclin D1 in cancer cells and the potential ...

In the late G1 phase, cyclin D1 levels increase and then activate CDK4/6, which helps trigger the progress of the cell cycle. In the S phase ...

Minireview: Cyclin D1: Normal and Abnormal Functions

Genetic aberrations in the regulatory circuits that govern transit through the G1 phase of the cell cycle occur frequently in human cancer, and overexpression ...

Cyclin D1 expression in B-cell lymphomas - ScienceDirect

For this reason, it has been considered that its overexpression in MCL cells leads to uncontrolled proliferation of malignant cells and tumor progression [3].

Functions of cyclin D1 as an oncogene and regulation of cyclin D1 ...

In addition, because esophageal cancer cells often overexpress FasL, resulting in protection from immune surveillance,) overexpression of cyclin ...

Aberrant Cyclin D1 splicing in cancer: from molecular mechanism to ...

Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, possesses many mutation types with different mutation frequencies in human ...

A Cyclin D1–Dependent Transcriptional Program Predicts Clinical ...

Gene Ontology (GO) analysis of the 295 genes activated by cyclin D1 showed a high enrichment of cell cycle and DNA damage, with 182 (62%) of them involved in ...

Cyclin D1 expression in peripheral T-cell lymphomas - Nature

Although cyclin D1 protein expression is well characterized in solid tumors and B-cell lymphomas, there are little data regarding cyclin D1 ...

The elements of human cyclin D1 promoter and regulation involved

Cyclin D1 is thought to play pivotal roles in G1-S phase transition. Mistakes in G1 phase may lead to cell cycle out of control and cause ...

Prevalence and clinical implications of cyclin D1 expression in ...

Cyclin D1 expression has been reported in a subset of patients with diffuse large B-cell leukemia (DLBCL), but studies have been few and generally small.

Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude ...

The cell survival oncoprotein Akt, also known as protein kinase. B, conveys distinct pathophysiological processes promoting cellular survival, ...

Cyclin D1 - Pathology Outlines

Comment: The tumor expresses CD5 and cyclin D1 in addition to other B cell markers, with a low proliferative index and negative CD23, consistent ...

Cyclin D - Wikipedia

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 ...

Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 ...

Cyclin D1 is the first cyclin produced in cell cycle in response to extracellular signals and allows quiescent cells to enter the G1 phase. Consistent with a ...

Transcriptional Activation of Cyclin D1 Promoter by FAK Contributes ...

Furthermore, we found that overexpression of ectopic cyclin D1 could rescue cell cycle inhibition by ΔC14. These results suggested that cyclin ...