Cytogenetics and genomics in pediatric acute lymphoblastic ...

The last five decades have witnessed significant improvement in diagnostics, treatment and management of children with acute lymphoblastic leukaemia (ALL).

Cytogenetics of paediatric and adolescent acute lymphoblastic ...

Cytogenetics has determined the incidence and prognostic significance of chromosomal abnormalities in acute lymphoblastic leukaemia (ALL).

Integrative genomic analysis of childhood acute lymphoblastic ...

Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has ...

The genomic landscape of pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2754 ...

Cytogenomic characterization of pediatric T-cell acute lymphoblastic ...

T-cell acute lymphoblastic leukemia (T-ALL) is a clinically and genetically heterogeneous disease that constitutes 10–15% of all newly diagnosed ...

A novel integrated cytogenetic and genomic classification refines ...

Recent genomic studies have provided a refined genetic map of acute lymphoblastic leukemia (ALL) and increased the number of potential prognostic markers.

Pediatric acute lymphoblastic leukemia - Haematologica

Historically, genetic factors identified by conventional karyotyping have been used to diagnose ALL and to risk-stratify children with the ...

Genomic Determinants of Outcome in Acute Lymphoblastic Leukemia

Genetic subtype, patterns of aneuploidy, and secondary genomic alterations determine risk of relapse in childhood ALL.

Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®) - NCI

For acute lymphoblastic leukemia (ALL), the 5-year survival rate has improved significantly since 1975. Get information about risk factors, ...

Childhood B-acute lymphoblastic leukemia: a genetic update

Advances in cytogenetics utilizing array-based technologies and next-generation sequencing (NGS) techniques have revealed exciting insights into ...

Redefining ALL classification: toward detecting high-risk ALL and ...

Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a leading cause of cancer death in the young. In the last decade, ...

Genomics and precision medicine in pediatric acute lymphoblastic ...

Acute lymphoblastic leukemia (ALL) is the most frequent malignant disease in the pediatric population, accounting for about 25% of childhood cancers.

Feasibility to use whole-genome sequencing as a sole diagnostic ...

Genetic characterization of acute lymphoblastic leukemia (ALL) is mandatory in modern treatment protocols since it provides important prognostic information, ...

The genomic landscape of pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of ...

Cytogenetics and Molecular Genetics of Acute Lymphoblastic ...

ALL is a genetic disease because most patients harbor acquired genetic alterations (somatic mutations) that contribute to the increased proliferation, ...

The genomic landscape of pediatric acute lymphoblastic leukemia 3 ...

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. In this genomepaint view mutations for each gene are displayed by ...

Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic ...

Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing ...

Childhood acute lymphoblastic leukemia: Integrating genomics into ...

Genomic alterations in T-ALL are often cytogenetically cryptic, and the prognostic impact of the various T-ALL-associated lesions identified to ...

The genomic landscape of pediatric acute lymphoblastic leukemia

Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low mutation burden, ALL ...

Childhood acute lymphoblastic leukemia: Integrating genomics into ...

In this review, the authors delineate the current genetic landscape of childhood ALL, emphasizing patient outcomes with contemporary treatment regimens.