DNA–Protein Cross|Links

DNA–Protein Cross-Links: Formation, Structural Identities, and ...

DNA–protein cross-links (DPCs) form when cellular proteins become covalently trapped on DNA strands upon exposure to various endogenous, ...

Crosslinking of DNA - Wikipedia

... DNA crosslinks, interstrand DNA crosslinks, and DNA-protein crosslinks. ... DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions".

DNA–protein crosslink proteases in genome stability - Nature

DNA–protein cross-links: formidable challenges to maintaining genome integrity. ... Translocation and stability of replicative DNA helicases upon ...

ChIP-X: Cross-linking proteins to DNA and cell lysis - Sigma-Aldrich

In some cases, target proteins are already tightly associated with DNA and additional chemical cross-links are not required to preserve the protein/DNA complex ...

DNA-Protein Cross-links: Formation, Structural Identities, and ...

DNA-protein cross-links (DPCs) form when cellular proteins become covalently trapped on DNA strands upon exposure to various endogenous, ...

DNA–protein cross-link repair: what do we know now?

The most well-known enzymatic DPCs are the covalent links between DNA and TOPs. Specifically, TOP1 relieves the torsional stress of DNA ...

Analysis of protein-DNA interactions in chromatin by UV induced ...

UV254 nm light induces zero-length cross-links between proteins and nucleic acids, i.e., only sites in immediate proximity are cross-linkable.

Crosslinking of DNA - an overview | ScienceDirect Topics

Interstrand DNA–DNA cross-links are highly toxic lesions that ... For quantification of target DNA fragments, the protein–DNA cross-links must be reversed.

Ubiquitin signaling and the proteasome drive human DNA–protein ...

A.D.. ,. O'Connor. T.R. Nucleotide excision repair eliminates unique DNA–protein cross-links from mammalian cells *.

Isolation and detection of DNA–protein crosslinks in mammalian cells

Enzyme mechanism-based, oxidative DNA–protein cross-links formed with DNA polymerase beta in vivo. Proc. Natl. Acad. Sci. U.S.A. 2015; 112 ...

Mechanisms and Regulation of DNA-Protein Crosslink Repair ...

Enzyme Mechanism-Based, Oxidative DNA-Protein Cross-Links Formed with DNA Polymerase β In Vivo. Proc. Natl. Acad. Sci. U.S.A. 112 (28), 8602–8607. doi ...

DNA–Protein Cross-Linking Sequencing for Genome-Wide Mapping ...

Thymidine glycol (Tg) is the most prevalent form of oxidatively induced pyrimidine lesions in DNA. Tg can arise from direct oxidation of ...

How to fix DNA-protein crosslinks - ScienceDirect.com

5-Formylcytosine mediated DNA–protein cross-links block DNA replication and induce mutations in human cells. Nucleic Acids Res., 46 (2018), pp. 6455-6469 ...

Enzymatic Processing of DNA–Protein Crosslinks - MDPI

Enzyme mechanism-based, oxidative DNA–protein cross-links formed with DNA polymerase β in vivo. Proc. Natl. Acad. Sci. USA 2015, 112, 8602–8607. [Google ...

Editorial: The repair of DNA–protein crosslinks - Frontiers

... DNA-protein cross-links in mammalian cells. J. Biol. Chem. 284, 27065–27076. doi:10.1074/jbc.M109.019174. PubMed Abstract | CrossRef Full ...

Does anyone have journal or experience to crosslinking of DNA and ...

1> choose your DNA carefully, not arbitrarily.DNA protein cross linking causes aging so think of something that accelerates DNA-Your-Protein ...

Abstract 1391 DNA-Protein Cross-Links: Formation and Repair ...

Genomic DNA wraps around histone octamers to form nucleosome core particles, the basic units of chromatin. Histones react with the apurinic/apyrimidinic ...

Site-specific cross-linking of proteins to DNA via a ... - RSC Publishing

DNA–protein cross-links (DPCs) are super-bulky DNA adducts induced by common chemotherapeutic agents, reactive oxygen species, and aldehydes, ...

DNA-Protein Cross-Links: Formation, Structural ... - EPA HERO

DNA-protein cross-links (DPCs) form when cellular proteins become covalently trapped on DNA strands upon exposure to various endogenous, environmental and ...

DNA-PROTEIN CROSSLINKS

Detecting DNA-Protein Crosslinks A number of methods have been developed for detecting DNA-protein cross-links (reviewed in Shetlar, 1980). The first method ...