DNA repair protein RAD50

RAD50 RAD50 double strand break repair protein [ (human)] - NCBI

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair.

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

The MRE11-RAD50-NBS1 (MRN) complex has a crucial role in DDR. It is one of the first sensors and responders to DNA damage and orchestrates DDR ...

RAD50, an SMC family member with multiple roles in DNA break ...

The protein complex including Mre11, Rad50, and Nbs1 (MRN) functions in DNA double-strand break repair to recognize and process DNA ends as well as signal ...

Rad50 - Wikipedia

DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene. RAD50. Identifiers. Aliases · RAD50, NBSLD, RAD502, ...

DNA repair protein RAD50 - Homo sapiens (Human) | UniProtKB

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and ...

Rad50 - an overview | ScienceDirect Topics

Rad50 is an ATP-dependent DNA-binding protein. Mre11 has several ... Rad50 and Rad51 are two proteins involved in DNA repair. Rad50 functions in ...

RAD50 Double Strand Break Repair Protein - GeneCards

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair.

p12753 · rad50_yeast - UniProt

Protein. DNA repair protein RAD50 · Gene. RAD50 · Status. UniProtKB reviewed (Swiss-Prot) · Organism. Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ( ...

Mre11-Rad50 oligomerization promotes DNA double-strand break ...

This localized MR accumulation then recruits a cascade of DNA repair and signaling proteins, including ATM/Tel1. Given that MR foci formation at ...

A dynamic allosteric pathway underlies Rad50 ABC ATPase ...

The Mre11-Rad50 protein complex is an initial responder to sites of DNA double strand breaks. Many studies have shown that ATP binding to ...

Structure of the Rad50 DNA double‐strand break repair protein in ...

Synopsis. image. The SMC protein Rad50 is a key subunit of the MRN complex, a repair factor involved in processing and tethering DNA double‐strand breaks. First ...

Modes of action of the archaeal Mre11/Rad50 DNA-repair complex ...

Mre11 and Rad50 (M/R) proteins are part of an evolutionarily conserved macromolecular apparatus that maintains genomic integrity through repair pathways.

Turning the Mre11/Rad50 DNA repair complex on its head

The bacterial SbcC/SbcD DNA repair proteins were identified over a quarter of a century ago. Following the subsequent identification of the ...

The dynamic nature of the Mre11-Rad50 DNA break repair complex

The Mre11-Rad50-Nbs1/Xrs2 protein complex plays a pivotal role in the detection and repair of DNA double strand breaks.

The coiled-coil of the human Rad50 DNA repair protein ... - PNAS

In this paper, we report the observation of striking irregularities in the flexibility of the coiled-coil region of the human Rad50 DNA repair protein.

Interaction of Mre11 and Rad50: two proteins required for DNA ...

Abstract. A temperature-sensitive mre11-1 mutation of Saccharomyces cerevisiae causes defects in meiotic recombination and DNA repair during vegetative gro.

DNA repair protein RAD50 (P12753) - InterPro - EMBL-EBI

DNA repair protein RAD50 ; Gene, RAD50 ; Function. Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination ...

Human DNA Repair Protein RAD50 (RAD50) ELISA Kit - MyBioSource

The ELISA analytical biochemical technique of the MBS2021902 kit is based on RAD50 antibody-RAD50 antigen interactions (immunosorbency) and an HRP colorimetric ...

Mre11–Rad50: the DNA end game | Biochemical Society Transactions

The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of ...

RAD50 | Cancer Genetics Web

Protein: DNA repair protein RAD50. Source: NCBIAccessed: 01 September, 2019. Ontology: What does this gene/protein do? Show (25). RAD50 is ...