Decrease of EphA4 does not alter motor function and survival in ...

Reducing EphA4 before disease onset does not affect survival in a ...

Reduction of EphA4 from developmental stages onwards rescued a motor neuron phenotype in zebrafish, and heterozygous deletion before birth in ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model ...

Reduction of EphA4 did not improve motor function, survival, motor neuron survival or NMJ innervation. Our data suggest that either lowering EphA4 has limited ...

Decrease of EphA4 does not alter motor function and survival in ...

Decrease of EphA4 does not alter motor function and survival in SMNΔ7 mice. Motor performance as assessed in the righting reflex test (A) and HLS test (B–E) ...

SMA Motor Function in Mice Does Not Improve With EphA4 Loss ...

Lowering the levels of the EphA4 gene is not enough to improve motor function and survival in a mouse model of severe spinal muscular atrophy, a study says.

Decreased signalling of EphA4 improves functional performance ...

Our novel results show that EphA4 signalling directly regulates motor neuron survival and that mutEphA4-Fc is a promising therapeutic candidate to slow disease ...

Antisense-mediated reduction of EphA4 in the adult CNS does not ...

In contrast, lowering of EphA4 in the CNS of two mouse models of ALS (SOD1G93A and PFN1G118V) did not improve their motor function or survival. Furthermore ...

EphA4 targeting agents protect motor neurons from cell death ...

The complex interplay between the EphA4 receptor and its ephrin ligands in motor neurons and astrocytes has not yet been fully elucidated and ...

Reducing EphA4 before disease onset does not affect survival in a ...

Reduction of EphA4 from developmental stages onwards rescued a motor neuron phenotype in zebrafish, and heterozygous deletion before birth in the SOD1G93A mouse ...

Modifying expression of EphA4 and its downstream targets improves ...

Reduction of EphA4 improved functional recovery as measured by rotarod, compared with baseline performance, at 29 days after the induction of stroke: 72.4 ± 4.9 ...

Role of EphA4 in Mediating Motor Neuron Death in MND - MDPI

However, the underlying mechanism of EphA4's function in MND is unclear. In this review, we first present results to demonstrate that EphA4 signalling acts ...

Article Potent and Selective EphA4 Agonists for the Treatment of ALS

Moreover, in humans with ALS, EphA4 expression correlates inversely with disease onset and overall survival, while loss-of-function mutations in EphA4 are ...

Inhibition of EphA4 reduces vasogenic edema after experimental ...

... EphA4 might function directly to reduce vasogenic edema. ... does not affect the steady-state of EphA4 transcription and EphA4 phosphorylation.

EphA4 (Sek1) receptor tyrosine kinase is required for the ... - PNAS

The function of the EphA4 (Sek1) receptor was explored through creation of a null mutant mouse. Mice with a null mutation in the EphA4 gene are viable and ...

Eph receptor A4 regulates motor neuron ferroptosis in spinal cord...

In conclusion, EphA4 participates in regulating ferroptosis of spinal motor neurons in the anterior horn in spinal cord ischemia/reperfusion injury by promoting ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model ...

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy ... Authors: Lindsay Poppe; Silke Smolders; Laura Rué; Mieke ...

Reduction of ephrin-A5 aggravates disease progression in ...

EphA4 genetic inhibition rescued the motor neuron phenotype in zebrafish and a rodent model of ALS. Preventing ligands from binding to the EphA4 ...

Modifying expression of EphA4 and its downstream targets improves ...

Our findings show that reduc- tion of EphA4 improves motor function after experimental stroke and demonstrate that ROCK inhibition is a.

Eph receptor A4 regulates motor neuron ferroptosis in spinal cord ...

Previous studies have shown that the receptor tyrosine kinase Eph receptor A4 (EphA4) is abundantly expressed in the nervous system.

Endothelial deletion of EPH receptor A4 alters single-cell profile and ...

EphA6 was shown to be up-regulated following TBI and correlated with a decrease in neurite density and motor function (16), while ephrinB2/EphB4 ...

Cooperation between GDNF/Ret and ephrinA/EphA4 Signals for ...

Earlier work indicated that the pathway into the dorsal limb by lateral motor column (LMC[l]) axons requires the EphA4 receptor, which mediates repulsion ...