Decreased function of survival motor neuron protein impairs ...

Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed survival motor neuron (SMN) protein, ...

Decreased function of survival motor neuron protein impairs ... - PNAS

SMN depletion causes defects in endosomal trafficking that impair synaptic function, even in the absence of motor neuron cell death.

Decreased function of survival motor neuron protein impairs endoc

elegans cholinergic motor neurons, decreased SMN levels caused aberrant localization of proteins critical for endocytosis. Significance. Spinal Muscular Atrophy ...

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA ...

The motor neuron disease spinal muscular atrophy (SMA) is caused by reduced levels of the survival of motor neuron (SMN) protein, ...

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA ...

Spinal muscular atrophy (SMA) is a neurodegenerative disease primarily affecting spinal motor neurons. It is caused by reduced levels of the ...

Decreased function of survival motor neuron protein ... - NASA ADS

Spinal muscular atrophy (SMA) is a devastating motor neuron disease, caused by decreased levels of the ubiquitous survival motor neuron (SMN) protein.

Decreased function of survival motor neuron protein impairs ...

Dive into the research topics of 'Decreased function of survival motor neuron protein impairs endocytic pathways'. Together they form a unique fingerprint ...

Survival Motor Neuron Protein - an overview | ScienceDirect Topics

In support of these human findings, studies using SMA mouse models have also documented impaired differentiation associated with reduced levels of SMN. shRNA- ...

The Survival of Motor Neuron Protein Acts as a Molecular ...

Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein.

(PDF) Decreased function of survival motor neuron protein impairs ...

PDF | Significance Spinal muscular atrophy (SMA) is a devastating motor neuron disease, caused by decreased levels of the ubiquitous survival motor.

Survival motor neuron protein deficiency impairs myotube formation ...

We found increased expression and reduced induction of key muscle development factors, such as MyoD and myogenin, with differentiation of SMN-deficient cells.

Decreased function of survival motor neuron protein impairs ...

Decreased function of survival motor neuron protein impairs endocytic pathways. Maria Dimitriadi, Aaron Derdowski, Geetika Kalloo, Melissa S. Maginnis ...

Survival Motor Neuron Protein in Motor Neurons Determines ...

Importantly, SMN also appears to function in muscle growth and/or maintenance independent of motor neurons. Our data suggest that SMN plays ...

The role of survival motor neuron protein (SMN) in protein ...

The survival motor neuron (SMN) protein was first highlighted as a protein of interest when mutations in its coding gene, SMN1, were linked to ...

Depletion of SMN Protein in Mesenchymal Progenitors Impairs the ...

Spinal Muscular Atrophy (SMA) is a neuromuscular disorder characterized by the deficiency of the survival motor neuron (SMN) protein, which ...

Reduced SMN protein impairs maturation of the neuromuscular ...

Spinal muscular atrophy (SMA) is a common pediatric neuromuscular disorder caused by insufficient levels of the survival of motor neuron (SMN) ...

SMN1 gene: MedlinePlus Genetics

The SMN1 gene provides instructions for making the survival motor neuron (SMN) protein. Learn about this gene and related health conditions.

Survival Motor Neuron Protein is Released from Cells in Exosomes

However, recent studies have shown that many different cell types and tissues also show impaired function in SMA. SMA is caused by a deficiency ...

Decreased function of survival motor neuron protein impairs ...

Dive into the research topics of 'Decreased function of survival motor neuron protein impairs endocytic pathways'. Together they form a unique fingerprint. Sort ...

Depletion of SMN Protein in Mesenchymal Progenitors Impairs the ...

advances our understanding of the role of the survival motor neuron (SMN) protein in coordinating pathogenesis of the spinal muscular atrophy ( ...