- Degrading proteins with intracellular antibodies🔍
- Targeted protein degradation using intracellular antibodies and its ...🔍
- Intracellular antibody|mediated degradation🔍
- Physiological Functions of Intracellular Protein Degradation🔍
- Intracellular Antibody|Mediated Degradation🔍
- Targeted protein degradation🔍
- Intracellular Protein Degradation and Its Therapeutic Implications🔍
- Applying Antibodies Inside Cells🔍
Degrading proteins with intracellular antibodies
Degrading proteins with intracellular antibodies | Nature Methods
Degrading proteins with intracellular antibodies ... Researchers develop a genetic method for degradation of GFP protein fusions in cells and ...
Targeted protein degradation using intracellular antibodies and its ...
This review will explore the mechanisms by which therapeutic antibodies engage and eliminate intracellularly aggregated proteins.
Intracellular antibody-mediated degradation - Wikipedia
Intracellular antibody-mediated degradation (IAMD) is a neutralization mechanism of intracellular antibody-mediated immunity whereby an effector protein, ...
Physiological Functions of Intracellular Protein Degradation - PubMed
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular ...
Intracellular Antibody-Mediated Degradation - News-Medical
Immune response was previously thought of as an extracellular process conducted by professional immune cells. Intracellular antibody-mediated degradation has ...
Targeted protein degradation: mechanisms, strategies and application
Lysosomes mediate the intracellular degradation of proteins and organelles in three different ways: endocytosis, phagocytosis, or autophagy (Fig ...
Intracellular Protein Degradation and Its Therapeutic Implications
Lysosomal and ubiquitin (Ub)-mediated protein degradation are two mechanisms for intracellular protein catabolism.
Applying Antibodies Inside Cells: Principles and Recent Advances ...
Recent advances in targeted degradation of proteins based on proteolysis-targeting chimaeras (PROTACs), ubiquibodies, deGradFP (degrade Green ...
Targeted protein degradation by Trim-Away using cell resealing ...
Intracellular delivery of antibodies has become a powerful tool for studying endogenous protein function. For example, fluorescent-labeled ...
Intracellular Antibodies for Drug Discovery and as Drugs of the Future
This results in proteosome degradation of targeted proteins [26], as intracellular antibody-E3 ligase fusions cause binary interactions between ...
Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted ...
Autophagy is responsible for the degradation of large intracellular contents, such as unwanted protein aggregates and organelles.
A Method for the Acute and Rapid Degradation of Endogenous ...
degrade endogenous proteins in unmodified cells by simply electroporating antibody and TRIM21 protein simultaneously. ... Antibodies mediate intracellular ...
Targeted Intracellular Delivery of Antibodies: The State of the Art
As already noted above, the property of most antibodies that limits their applications to targeting extracellular proteins is their inability to cross cellular ...
A Promising Intracellular Protein-Degradation Strategy: TRIMbody ...
Protein depletion or degradation technologies are widely used for researchers to understand the biological functions of intracellular proteins, ...
Targeting extracellular and membrane proteins for degradation ...
Sweeping antibodies and Seldegs use Fc receptors in conjunction with engineered antibodies to degrade soluble proteins. Recently, lysosome- ...
Protein degradation is the process by which proteins are naturally destroyed in a cell in order to maintain protein homeostasis, or an equilibrium of proteins ...
Targeted protein degradation in lysosome utilizing naturally ...
Novel antibodies have been created for targeted degradation of extracellular and membrane proteins in the lysosome. The mechanism of degradation ...
Targeted Degradation of Cell‐Surface Proteins via Chaperone ...
Herein, we report antibody–peptide conjugates (Ab-CMAs) in which a peptide targeting chaperone-mediated autophagy (CMA) was conjugated with ...
Development of Antibody-Based PROTACs for the Degradation of ...
Targeted protein degradation has emerged as a new paradigm to manipulate cellular proteostasis. Proteolysis-targeting chimeras (PROTACs) are ...
Protocol to select conformation-specific intracellular antibodies for ...
The F-box/intrabody-mediated protein degradation represents a unique approach to selectively target the active form of small GTPases or other ...