Destabilizing heterochromatin by APOE mediates senescence.

Destabilizing heterochromatin by APOE mediates senescence

Our findings uncover a role of APOE as an epigenetic mediator of senescence and provide potential targets to ameliorate aging-related diseases.

Destabilizing heterochromatin by APOE mediates senescence

We report that in aged human mesenchymal progenitor cells (MPCs), APOE accumulation is a driver for cellular senescence. By contrast, CRISPR-Cas9-mediated ...

(PDF) Destabilizing heterochromatin by APOE mediates senescence

We report that in aged human mesenchymal progenitor cells (MPCs), APOE accumulation is a driver for cellular senescence. By contrast, CRISPR– ...

Destabilizing heterochromatin by APOE mediates senescence.

We report that in aged human mesenchymal progenitor cells (MPCs), APOE accumulation is a driver for cellular senescence. By contrast, CRISPR-Cas9-mediated ...

Science Update---Institute For Stem Cell And Regeneration,CAS

APOE destabilizes heterochromatin and drives senescence · Prof. · APOE is well known as a classical lipid-transport protein that mediates lipid transport.

APOE Induces MSC Senescence by Disrupting Chromatin - EpiGenie

Overall, this well-balanced study provides evidence that stem cell senescence triggered by APOE-mediated heterochromatin destabilization may ...

Destabilizing heterochromatin by APOE mediates senescence.

Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022 Apr;2(4):303-316. Epub 2022 Mar 28 PubMed.

Destabilizing heterochromatin by APOE mediates senescence - OUCI

Destabilizing heterochromatin by APOE mediates senescence. https://doi.org/10.1038/s43587-022-00186-z. Journal: Nature Aging, 2022, № 4, p. 303-316. Publisher ...

[Article] Destabilizing heterochromatin by APOE mediates senescence

[Article] Destabilizing heterochromatin by APOE mediates senescence. Found. DOI: 10.1038/s43587-022-00186-z. PMID: 37117743 URL: https://www ...

Apolipoprotein E destabilizes heterochromatin and drives senescence

Results were published in Nature Aging on March 28. APOE is well known as a classical lipid-transport protein that mediates lipid transport.

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... APOE overexpression promoted hMPC senescence. By contrast, hMPCs lacking ... Destabilizing heterochromatin by APOE mediates senescence, Nature Aging ...

CRISPR screening uncovers nucleolar RPL22 as a heterochromatin ...

H. et al. . Destabilizing heterochromatin by APOE mediates senescence . Nat. Aging . 2022. ;. 2. : 303. –. 316 . Google Scholar · Crossref.

Pluchino lab | Nature Aging https://t.co/zM2UCa71CR" - X

Destabilizing heterochromatin by APOE mediates senescence | Nature Aging https://t.co/zM2UCa71CR.

Barasertib impedes chondrocyte senescence and alleviates ...

... destabilized heterochromatin and caused senescence in chondrocytes. Fig ... Yan, et al. Destabilizing heterochromatin by APOE mediates senescence. Nat ...

APOE Loss of Function Variants | ALZFORUM

Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022 Apr;2(4):303-316. Epub 2022 Mar 28 PubMed. Wang C, Najm R, Xu Q ...

Relationships between protein degradation, cellular senescence ...

... Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2, 303–316 [PubMed] [Google Scholar]. 53. Choi, I., Wang, M., Yoo, S., Xu, P., Seegobin ...

Apolipoprotein E regulates chromatin stability and senescence

Nuclear APOE promotes senescence by destabilizing heterochromatin, a regulator of lipid metabolism and is genetically associated with longevity and ...

The model for heterochromatin reorganization in senescent cells ...

Destabilizing heterochromatin by APOE mediates senescence. Article. Full-text ... heterochromatin (Zhang et al., 2021) during aging or senescence. We ...

CRISPR screening uncovers nucleolar RPL22 as a heterochromatin ...

... heterochromatin protein 1γ (HP1γ) and heterochromatin protein. KRAB ... (2022) Destabilizing heterochromatin by. APOE mediates senescence.

The sirtuin-associated human senescence program converges on ...

125. Zhao, H. ∙ Ji, Q. ∙ Wu, Z. ... Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022; 2:303-316. Crossref · Scopus (28) · PubMed.