Development of a Novel Lysophosphatidic Acid Activity Probe to ...

Cuthriell, Leah M., "Development of a Novel Lysophosphatidic Acid Activity Probe to Identify and. Characterize New Protein Targets. " Master's Thesis ...

"Development of a Novel Lysophosphatidic Acid Activity Probe to ...

Lipids are categorized according to their biological function. Phospholipids, glycolipids, and cholesterol are bulk membrane lipids that offer structure and ...

Design and Development of Autotaxin Inhibitors - PMC - NCBI

... activities to lysophosphatidic acid ... A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation.

Establishment of a novel, cell-based autotaxin assay - ScienceDirect

Cell-based assay for detection of ATX activity using a lysophosphatidic acid (LPA) receptor reporter cell line. •Characterization of ATX ...

Chemical Proteomic Profiling of Lysophosphatidic Acid-Binding ...

By combining this strategy with SILAC, we were able to characterize LPA–protein interactions at the entire proteome, which resulted in the ...

A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1 ...

Pharmacological options for NP are limited and slightly effective, so there is a need of developing more efficacious NP attenuating drugs. Activation of the ...

Structural mechanisms of potent lysophosphatidic acid receptor 1 ...

Recently reported nonlipid LPA1-3 agonists are uniquely potent, selective, and especially stable compared to LPA, and are excellent tools for ...

Synthesis and Biological Evaluation of Lysophosphatidic Acid ...

Lysophosphatidic acid (LPA) is a key player in many physiological and pathophysiological processes. The biological activities of LPA are ...

2-Carba-lysophosphatidic acid is a novel β ... - Nature

Thus, not only cPA but also its degradation compound may contribute to the biological activity of cPA, at least for 2ccPA. In this study, we ...

Lysophosphatidic acid produced by autotaxin acts as an allosteric ...

We found that ATX activity is stimulated by LPA and that LPA activates ATX lysophospholipase D activity by binding to the ATX tunnel.

Lysophosphatidic Acid Receptors Determine Tumorigenicity and ...

AbstractBackground. Lysophosphatidic acid (LPA) acts through the cell surface G protein–coupled receptors, LPA1, LPA2, or LPA3, to elicit a wide range of c.

Aiming drug discovery at lysophosphatidic acid targets - Tigyi - 2010

There are two mouse phospholipase A1 enzymes that have been linked to production of unsaturated sn-2 LPA. A phosphatidic acid-specific PLA1α and ...

Promising Pharmacological Directions in the World of ...

Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. These receptors initiate ...

Lysophosphatidic Acid (LPA) Receptor 3-Mediated LPA Signal ...

LPA appears to play a significant role in many reproductive processes, including luteolysis, implantation, and placentation. Our previous study in pigs ...

Novel lysophosphatidic acid receptor - Google Patents

It is intended to provide a novel receptor of LPA and a method of screening a drug such as an LPA receptor antagonist using the same.

Role of phospholipase D in agonist-stimulated lysophosphatidic ...

SK-OV-3 cells express and secrete a phospholipase A2 activity that can generate LPA from the lipid product of PLD, phosphatidic acid. Our results identify a ...

In vitro pharmacological characterization of standard and new ...

Lysophosphatidic acid (LPA) is a bioactive phospholipid that acts as an agonist of six G protein-coupled receptors named LPA receptors ...

Identification and Characterization of a Novel Lysophosphatidic Acid ...

We also found that 2-acyl-LPA had higher activity to p2y5 than 1-acyl-LPA. A recent study has suggested that p2y5 is an LPA receptor essential for human hair ...

Lysophosphatidic acid: a novel growth and survival factor for renal ...

LPA is a normal constituent of serum and binds with high affinity to albumin while retaining its biological activity. The effects of LPA are pleiotropic and ...

Lysophosphatidic acid signalling in development | Request PDF

... In addition, it was shown that LPA contributes to the processes of endothelial cell proliferation, migration and differentiation that all essential for ...