Dexmedetomidine and Propofol Sedation in Critically Ill Patients and ...

The SPICE III (Sedation Practice in Intensive Care Evaluation) trial reported significant heterogeneity in mortality with dexmedetomidine treatment.

Dexmedetomidine and Propofol Sedation in Critically Ill Patients

As with the primary analysis, the repeated resampling process found increasing mean propofol infusion rate with steady mean dexmedetomidine was associated with ...

Outcomes of dexmedetomidine versus propofol sedation in critically ...

Dexmedetomidine did not significantly impact ICU length of stay compared with propofol, but it significantly reduced the duration of mechanical ventilation and ...

Effects of dexmedetomidine versus propofol on outcomes in critically ...

In the current study, the DEX group had a significantly higher median RASS score throughout the ICU stay, thus achieving light sedation depth in more cases, ...

Dexmedetomidine or Propofol for Sedation in Mechanically ...

We found no difference between dexmedetomidine and propofol in the number of days alive without delirium or coma (adjusted median, 10.7 vs. 10.8 ...

Use of dexmedetomidine in critical-ill patients: is it time to look to the ...

Dexmedetomidine is an alpha-2 (ɑ2) adrenergic receptor and imidazoline type 2 receptor agonist that received Food and Drug Administration ...

Dexmedetomidine versus midazolam and propofol for sedation in ...

Propofol is also a preferred sedative for ICU patients because of its short duration of effect and quick onset. Dexmedetomidine, a highly selective alpha-2 ...

Dexmedetomidine versus propofol for prolonged sedation in ...

Our results suggest that, similar to medical and cardiac surgery patients, dexmedetomidine and propofol are safe and effective sedation agents in critically ...

Early Sedation with Dexmedetomidine in Critically Ill Patients

Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium.

Dexmedetomidine vs Midazolam or Propofol for Sedation During ...

Dexmedetomidine, an α2-agonist available for ICU sedation, may reduce the duration of mechanical ventilation and enhance patient comfort.

Dexmedetomidine and Propofol Sedation in Critically Ill Patients and ...

Conclusions. In patients ⩽65 years of age sedated with dexmedetomidine and propofol combination, preferentially increasing the dose of propofol ...

Dexmedetomidine and Propofol Sedation in Critically Ill Patients

Background: Use of nonbenzodiazepine agents propofol and dexmedetomidine are first line for sedation in the intensive care unit (ICU). These agents have been ...

Dexmedetomidine vs midazolam for sedation of critically ill patients

At comparable sedation levels, dexmedetomidine-treated patients spent less time on the ventilator, experienced less delirium, and developed less tachycardia ...

Dexmedetomidine and propofol sedation in critically ill patients and ...

Abstract. Rationale: The SPICE III (Sedation Practice in Intensive Care Evaluation) trial reported significant heterogeneity in mortality with ...

Dexmedetomidine and Propofol Sedation in Critically Ill Patients and ...

Conclusions: In patients ⩽65 years of age sedated with dexmedetomidine and propofol combination, preferentially increasing the dose of propofol was associated ...

Dexmedetomidine vs Midazolam for Sedation of Critically Ill Patients

For decades, γ-aminobutyric acid (GABA) receptor agonists (including propofol and benzodiazepines such as midazolam) have been the most commonly ...

Dexmedetomidine and Propofol Sedation in Critically Ill Patients and ...

Conclusions: In patients <65 years of age sedated with dexmedetomidine and propofol combination, preferentially increasing the dose of propofol ...

Dexmedetomidine: its use in intensive care medicine and anaesthesia

The improved specificity of dexmedetomidine for the α2-receptor makes it a more effective sedative than clonidine. Patients at particular risk of critical care ...

Dexmedetomidine and Propofol Sedation in Critically Ill Patients and ...

Conclusion: In patients ≤ 65 years sedated with dexmedetomidine and propofol combination, preferentially increasing the dose of propofol was ...

study protocol for a randomised placebo-controlled trial | BMJ Open

12 In addition previous studies has suggested that critically ill patients, treated with dexmedetomidine during nights has increased sleep efficiency and ...