Different contributions of local| and distant|regulatory changes ...

Different contributions of local- and distant-regulatory changes to ...

We conducted expression quantitative trait loci (eQTL) analysis to investigate the genetic architecture underlying transcriptome divergence between marine and ...

Different contributions of local- and distant-regulatory changes to ...

Different contributions of local- and distant-regulatory changes to transcriptome divergence between stickleback ecotypes. Asano Ishikawa, Makoto Kusakabe ...

Contributions of Protein-Coding and Regulatory Change to Adaptive ...

... local variation in constraint or mutation rate. Notably, we still ... This analysis can only qualitatively compare the fit of different models, ...

and distant-regulatory changes to transcriptome divergence ...

Different contributions of local- and distant-regulatory changes to transcriptome divergence between stickleback ecotypes. Evolution. 2017 Mar;71(3):565-581 ...

Human gene regulatory evolution is driven by the divergence of ...

... changes each contribute to the differential activity of many regulatory ... local and precise cis changes to DNA regulatory elements.

Differential contribution of transcriptomic regulatory layers in the ...

... change in gene expression between these two groups). Fig. 3: GE and APA changes in LF2 distinguish proximal-distal neurons from other axes.

Genetics of trans-regulatory variation in gene expression - eLife

Contribution of local and distant eQTLs to expression variance. (A) ... changes caused by different types of eQTLs remain a key area for ...

Cis and trans effects differentially contribute to the evolution of ...

Changes in non-coding regulatory elements—including promoters and enhancers—are particularly important in driving the evolution of gene ...

Comparative studies of gene regulatory mechanisms - ScienceDirect

... changes in cis regulatory elements [19•, 20]. These studies have also uncovered substantial and previously under-appreciated contributions from changes in ...

Emerging principles of regulatory evolution - PNAS

... regulatory changes are more likely to contribute to morphological evolution. ... regulatory changes are more commonly favored over other ...

The regulatory landscapes of developmental genes | Development

Summary: This Development at a Glance article gives an overview of the complexity of regulatory landscapes, highlighting different modes of ...

The role of regulatory variation in complex traits and disease - Nature

In both yeast and humans, the effects of distant eQTLs can change considerably in different environments. ... local sequence effects and different ...

Tissue-specific and cis-regulatory changes underlie parallel ... - PLOS

Such mutations can arise in cis- (near the gene of interest) or in trans- (at a distant locus), but the relative contribution of these different kinds of ...

Inheritance of Gene Expression Level and Selective Constraints on ...

Gene expression evolution can be caused by changes in cis- or trans-regulatory elements or both. As cis and trans regulation operate through different molecular ...

Evolution of cis- and trans-regulatory divergence in the chicken ...

Since our pipeline only counted the local reads containing the heterozygous SNPs, we further assessed the expression fold change (CG/WL) ...

Cis‐regulatory variation in plant genomes and the impact of natural ...

lyrata, instead, cis-regulatory variants have markedly contributed to increase the basal expression level of cold-responsive genes (Akama et al.

Differential roles of epigenetic changes and Foxp3 expression in ...

5), Treg-specific DNA hypomethylated regions and Foxp3 binding regions were mostly different in Treg cells (Fig. 6A). To examine each contribution to the Treg- ...

Predominance of cis-regulatory changes in parallel expression ...

Many studies have reported that cis-regulatory differences contribute strongly to divergence in gene regulation over long evolutionary ...

Hodges lab sheds new light on mechanisms of gene regulatory ...

... method to separate the relative contributions of cis vs. trans regulatory mechanisms to gene regulatory divergence between species.

Local and distant regulatory variation. (a) Local ... - ResearchGate

... different types of distantly ... Recent advances suggest that subtle variations in the regulation of gene expression may contribute to quantitative traits.