Differential DNA Damage Response in Stem and Progenitor Cells

Differential DNA damage response in stem and progenitor cells

The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem ...

The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells.

Differential DNA Damage Response in Stem and Progenitor Cells

The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem Cell, ...

Review DNA Damage in Stem Cells - ScienceDirect.com

Inducible pluripotent stem cells also display a robust DNA damage response, but the stability of their genome is often conditioned by the ...

Differential DNA Damage Response in Stem and Progenitor Cells

The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem ...

DNA-damage response in hematopoietic stem cells - Oxford Academic

Recent observations exposed remarkable differences in several DNA-damage response (DDR) aspects between HSCs and Progenitors, especially in their DNA-repair ...

DNA damage tolerance in hematopoietic stem and progenitor cells ...

The DNA damage response entails both DNA repair and DNA damage tolerance (DDT). DDT enables replicative bypass of fork-stalling DNA lesions ...

The Bright and the Dark Sides of DNA Repair in Stem Cells - 2010

Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon differentiation, a certain degree of somatic mutations becomes ...

DNA damage and repair in differentiation of stem cells and cells of ...

In general, pluripotent stem cells possess stronger DNA repair systems compared to the differentiated cells. Nonetheless, during a prolonged ...

DNA Damage in Stem Cells

programming of terminally differentiated cells (Box 2). iPSCs can ... etic stem and progenitor cell mutagenesis in response to DNA damage.

Reprogramming and differentiation-dependent transcriptional ...

The DNA damage response (DDR) is highly organized by several molecular mechanisms, such as DNA repair, cell cycle checkpoints and apoptosis (programed cell ...

Lnc956 regulates mouse embryonic stem cell differentiation in ...

In response to DNA damage in PSCs, the primary function of p53 is to induce stem cell differentiation (14–16). A global examination of p53 ...

DNA damage in stem cells activates p21, inhibits p53, and induces ...

These findings suggest that stem cells have evolved a unique, p21-dependent response to DNA damage that leads to their immediate expansion and limits their long ...

DNA Damage Response and Cell Cycle Regulation in Pluripotent ...

In 2006, Yamanaka and his team reported the generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblasts through induction of ...

Pluripotent Stem Cells and DNA Damage Response to Ionizing ...

To maintain genomic stability and avoid transmission of mutations into progenitors cells, stem cells have robust DNA damage response signaling, ...

Pluripotent Stem Cells and DNA Damage Response to Ionizing ...

Stem cell transplantation may protect against radiation-induced late effects. In particular, this review focuses on differential DNA damage response between ...

Differential DNA Damage Response in Stem and Progenitor Cells

Differential DNA Damage Response in Stem and Progenitor Cells. https://doi.org/10.1016/j.stem.2010.07.006 · Full text. Journal: Cell Stem Cell, 2010, № 2, p.

[PDF] DNA Damage Response in Hematopoietic Stem Cell Ageing

Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging · Biology, Medicine. Cell cycle · 2007.

Hematopoietic stem/progenitor cells are less prone to undergo ...

Kraft et al. analyzed DNA damage response in activated CD34+ cells derived from peripheral blood as compared to peripheral blood lymphocytes [20] ...

A coordinated DNA damage response promotes adult quiescent ...

The response of stem cells to DNA damage is poorly understood, although there is increasing evidence that they respond distinctly to differentiated cells. We ...