Differential transcriptional profiles identify microglial

Our search for microglial- and macrophage-specific cell surface markers through RNA-Seq revealed that P2yr12, Mrc2, and Pros1 were specifically ...

and macrophage-specific gene markers expressed during virus ...

Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation.

Transcriptional profiling in microglia across physiological and ...

Analysis of germ-line DNA identified genes with variants associated with AD and MS that are overrepresented in microglial gene sets, including ...

Transcriptional profiling of microglia; current state of the art and ...

Comparison with peritoneal macrophages identified 626 differentially expressed transcripts and the top 25 most highly expressed microglia transcripts include ...

Microglial Differential Transcriptional Profiles in the Late-Stage ...

Mice were characterized via behavior testing for motor deficit prior to microglia isolation and RNA extracted for RNA-sequencing. A total of ...

Differential transcriptional response profiles in human myeloid cell ...

Current markers used to distinguish microglia and MDMs have been defined under homeostatic conditions. We observe that gene expression profiles of M1 microglia ...

Overview of General and Discriminating Markers of Differential ...

Shifting between microglial phenotypes has recently become a therapeutic approach in multiple CNS diseases. Definite description of microglia profiles is an ...

Differential transcriptional profiles identify microglial - ResearchGate

Conclusions: The differential expression of cell surface-specific genes during neuroinflammation can potentially be used to discriminate between ...

Human microglia show unique transcriptional changes in ... - Nature

We identify microglial phenotypes more prevalent in AD cases compared with controls. Further, we describe the heterogeneity in microglia ...

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial ...

Using these modules to interpret single-cell data from an Alzheimer's disease (AD) model, we identified microglial subsets—distinct from previously reported “ ...

and macrophage-specific gene markers expressed during virus ...

Table 1 List of 50 cell surface candidate genes specifically expressed by microglia or infiltrating macrophages. From: Differential transcriptional profiles ...

Microglia states and nomenclature: A field at its crossroads

Their morphology, ultrastructure, and molecular profile are similarly dynamic and plastic, resulting in many different cell states. As Conrad H.

Differential transcriptional profiles mediated by exposure to the ...

The y axis shows the top eight most high-level functions and canonical pathways associated with genes regulated in CBD-treated BV-2 microglial ...

and macrophage-specific gene markers expressed during virus - OUCI

Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation ... Authors: Ana ...

The Transcriptional Landscape of Microglial Genes in Aging and ...

Using CellMapper and TMEM119 as a marker of native microglia, we identified 30 additional genes associated with a microglial gene expression profile (Table 2; p ...

Microglial Transcriptional Signatures in the Central Nervous System

Microglial gene expression signatures can help distinguish them from macrophage cell types to a reasonable degree of certainty, depending on the ...

Microglia show differential transcriptomic response to Aβ peptide ...

We find that primary microglial cultures have rapid and massive transcriptional change in response to Aβ.

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial ...

In this meta-analysis of CNS myeloid cell expression profiles, Friedman et al. identify gene modules associated with diverse microglial ...

Profiling Microglia in a Mouse Model of Machado–Joseph Disease

Aging causes microglia to adopt an aberrant phenotype, sometimes referred to as dystrophic or senescent, usually associated with a decreased ability to provide ...

New tools for studying microglia in the mouse and human CNS | PNAS

To identify a microglia-specific marker, we generated a microglia-enriched gene expression profile of CD45+ immunopanned brain leukocytes from adult mice (18).