Disease heterogeneity and personalized prognosis in ...

Background. Myeloproliferative neoplasms (MPN), comprising polycythemia vera, essential thrombocythemia and myelofibrosis, are chronic hematological ...

Disease heterogeneity and personalized prognosis in myeloproliferative neoplasms. / Grinfeld, Jacob ; Nangalia, Jyoti ; Baxter, E Joanna ; Wedge, David C ; ...

Classification and Personalized Prognosis in Myeloproliferative ...

This complex genetic landscape probably contributes to heterogeneity in diagnostic features and outcomes in patients with myeloproliferative ...

Disease heterogeneity and personalized prognosis in ...

Grinfeld, Jacob ; Nangalia, Jyoti ; Baxter, E Joanna ; Wedge, David C ; Angelopoulos, Nicos ; Cantrill, Robert ; Godfrey, Anna L ; Papaemmanuil, ...

Molecular Heterogeneity in Leiomyosarcoma and Implications for ...

Molecular Heterogeneity in Leiomyosarcoma and Implications for Personalised Medicine ... Curr Treat Options Oncol. 2024 May;25(5):644-658. doi: ...

Genomic, pathological, and clinical heterogeneity as drivers of ...

As such, better predictors of individualized prognosis and treatment response are urgently needed to triage patients to customized and intensified CaP treatment ...

Clonal architecture evolution in Myeloproliferative Neoplasms - Nature

In the recent years, disease heterogeneity has been mainly linked to the diversity of genetic lesions found in patients' hematopoietic stem ...

Unraveling patient heterogeneity in complex diseases through ...

Individualized gene networks have emerged as valuable tools for personalized medicine, allowing for identifying disease-associated biomarkers ...

Genomic heterogeneity in myeloproliferative neoplasms and ...

Factors influencing disease phenotype and clinical progression · Genomic testing in the clinical setting · Conclusion · Future considerations · Declaration of ...

Classification and Personalized Prognostic Assessment on the ...

By integrating 63 clinical and genomic variables, we define a novel prognostic model that generates personally tailored predictions of survival.

Are we ready for disease modification in myeloproliferative ...

Myeloproliferative neoplasms (MPN) are chronic myeloid diseases characterized by clinical heterogeneity ... Classification and personalized ...

Platelet Heterogeneity in Myeloproliferative Neoplasms

MPNs encompass a spectrum of disease entities with progressively more severe clinical features, including complications with thrombosis and ...

Genetic basis and molecular profiling in myeloproliferative neoplasms

MPN is a genetically heterogeneous disease in which germline and somatic mutations contribute to disease initiation and the course of disease.

Loss of hematopoietic progenitors heterogeneity is an adverse ...

Indeed, MDS display marked heterogeneity regarding the prognosis and the risk of disease progression which is assessed by the revised ...

Advances in Molecular Understanding of Polycythemia Vera ... - MDPI

... personalized therapeutic strategies by elucidating the genetic intricacies that underpin disease heterogeneity, prognosis, and therapeutic response.

Impact of genetic dynamics and single-cell heterogeneity on ... - PNAS

Current personalized medicine matches therapy to a tumor molecular profile at diagnosis and at tumor relapse or progression, generally focusing ...

Towards a Personalized Definition of Prognosis in Philadelphia ...

The biological complexity of MPNs and its role on the trajectory of disease outcome have led to the design of integrated prognostic models that ...

Leukemia secondary to myeloproliferative neoplasms | Blood

... disease heterogeneity is changing how we better identify patients at high risk for progression. ... , et al. Classification and personalized ...

Phenotypical heterogeneity of acute myeloid leukemia in the elderly

A correlation between OS and phenotypic heterogeneity has been observed, i.e. OS reduces with the heterogeneity rising and this difference is ...

Molecular pathogenesis of the myeloproliferative neoplasms

With the increasing availability of genetic sequencing in the research and now routine diagnostic setting, the genetic heterogeneity of the MPN ...