Disrupting B and T|cell collaboration in autoimmune disease

Disrupting B and T-cell collaboration in autoimmune disease

B and T cells collaborate to drive autoimmune disease (AID). Historically, B- and T-cell (B-T cell) co-interaction was targeted through ...

Disrupting B and T-cell collaboration in autoimmune disease

We discuss the potential mechanistic advantages of novel therapies that rely on T cells as effector cells to disrupt B–T-cell collaboration toward overcoming ...

Disrupting B and T cell Collaboration in Autoimmune Disease - OSF

In the treatment of cancer, chimeric antigen receptor (CAR) T cell therapy and T cell engagers (TCE) that recruit T cells to induce B cell cytotoxicity have ...

Disrupting B and T-cell collaboration in autoimmune disease - OUCI

Summary B and T cells collaborate to drive autoimmune disease (AID). Historically, B- and T-cell (B–T cell) co-interaction was targeted through different ...

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune ...

Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathogenesis by disrupting B cell anergy.

Switching off autoimmunity - Science

Current clinical trials are designed on the premise that CD40L blockade will disrupt T and B cell activation and ameliorate inflammation. A ...

Bi-specific autoantigen-T cell engagers as targeted immunotherapy ...

Introduction: In autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating B cells. However, current first-line treatments rely ...

B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and ...

... B- and T-cell subsets driving MS disease activity. ... IFN-γ is a key player in autoreactive B- and Th-cell interaction and autoimmune germinal center (GC) ...

Pathogenesis of autoimmune disease | Nature Reviews Nephrology

B and/or T cell reactivity signifies a disturbance of immune tolerance and is essential to the development of autoimmunity. The extent of these ...

Development of Lupus-like Autoimmune Diseases by Disruption of ...

Furthermore, CD8+2C-TCR+PD-1−/− T cells exhibited markedly augmented proliferation in vitro in response to H-2d allogenic cells. Collectively, it is suggested ...

B cell checkpoints in autoimmune rheumatic diseases

T cells and B cells, respectively) to disrupt TFH cell–. B ... activation, expansion, and plasma cell generation during CD4+ T cell- B cell collaboration.

The link between circulating follicular helper T cells and autoimmunity

Follicular helper T (TFH) cells classically reside in secondary lymphoid organs where they support germinal centre (GC) B cell responses; ...

Activated B cells suppress T-cell function through metabolic ...

Background B cells play a pivotal role in regulating the immune response. The induction of B cell-mediated immunosuppressive function requires B cell ...

Activation Markers on B and T Cells and Immune Checkpoints in ...

In addition to identifying the major B- and T-cell subpopulations involved in autoimmune rheumatic diseases (ARDs), in recent years special attention has ...

Disruption of memory B-cell trafficking by belimumab in patients with ...

Autoreactive memory B cells (MBCs) contribute to chronic and progressive courses in autoimmune diseases like SLE. The efficacy of belimumab (BEL), ...

T-Cell‒Mediated Autoimmunity: Mechanisms and Future Directions

T cells are key drivers of autoimmunity in numerous noncommunicable inflammatory skin diseases by directly harming host tissue or through helping B cells in ...

Cutting Edge: Direct Suppression of B Cells by CD4 + CD25 + ...

Regulatory T cells (Tregs) appear to play important roles in regulation of B cell Ig response. In several autoimmune diseases with aberrant Ab production, the ...

CAR T cells in autoimmune disease: On the road to remission

In autoimmune diseases, autoreactive B cell clones and autoantibodies against a patient's own antigens can form long before clinical symptoms ...

B cell-targeting chimeric antigen receptor T cells as an emerging ...

In autoimmune diseases, B cells not only act as producers of autoantibodies, but they can also present self-peptides through MHC, thereby activating ...

Possible trigger for autoimmune diseases disc - EurekAlert!

Possible trigger for autoimmune diseases discovered: B cells teach T cells which targets must not be attacked · Immune cells must learn not to ...