- Disrupting B and T|cell collaboration in autoimmune disease🔍
- Disrupting B and T cell Collaboration in Autoimmune Disease🔍
- CAR T cells in autoimmune disease🔍
- Renegade T cell clones and autoimmune disease🔍
- Switching off autoimmunity🔍
- Bi|specific autoantigen|T cell engagers as targeted immunotherapy ...🔍
- The link between circulating follicular helper T cells and autoimmunity🔍
- T Cell/B Cell Collaboration and Autoimmunity🔍
Disrupting B and T cell Collaboration in Autoimmune Disease
Disrupting B and T-cell collaboration in autoimmune disease
We discuss the potential mechanistic advantages of novel therapies that rely on T cells as effector cells to disrupt B–T-cell collaboration toward overcoming ...
Disrupting B and T-cell collaboration in autoimmune disease
B and T cells collaborate to drive autoimmune disease (AID). Historically, B- and T-cell (B-T cell) co-interaction was targeted through ...
Disrupting B and T cell Collaboration in Autoimmune Disease - OSF
In the treatment of cancer, chimeric antigen receptor (CAR) T cell therapy and T cell engagers (TCE) that recruit T cells to induce B cell cytotoxicity have ...
Disrupting B and T-cell collaboration in autoimmune disease - OUCI
Summary B and T cells collaborate to drive autoimmune disease (AID). Historically, B- and T-cell (B–T cell) co-interaction was targeted through different ...
CAR T cells in autoimmune disease: On the road to remission
In autoimmune diseases, autoreactive B cell clones and autoantibodies against a patient's own antigens can form long before clinical symptoms ...
Renegade T cell clones and autoimmune disease - PMC - NCBI
The emergence of Tfh cells as a key player in this autoantibody-mediated disorder is not surprising, given their central contribution to B cell ...
Switching off autoimmunity - Science
Current clinical trials are designed on the premise that CD40L blockade will disrupt T and B cell activation and ameliorate inflammation. A ...
Bi-specific autoantigen-T cell engagers as targeted immunotherapy ...
Introduction: In autoimmune diseases, autoreactive B cells comprise only the 0.1-0.5% of total circulating B cells. However, current first-line treatments rely ...
The link between circulating follicular helper T cells and autoimmunity
Follicular helper T (TFH) cells provide help to B cells, supporting the formation of germinal centres that allow affinity maturation of ...
T Cell/B Cell Collaboration and Autoimmunity: An Intimate ... - Frontiers
Given that chronic autoimmune diseases may be sustained by the perpetuation, rather than initiation, of self-directed immune responses, the bi-directional ...
B cell-targeting chimeric antigen receptor T cells as an emerging ...
In autoimmune diseases, B cells not only act as producers of autoantibodies, but they can also present self-peptides through MHC, thereby activating ...
T cells in health and disease | Signal Transduction and Targeted ...
Abnormal T-cell immunity can initiate and promote the pathogenesis of autoimmune diseases. In this review, we summarize the current ...
Activated B cells suppress T-cell function through metabolic ...
Background B cells play a pivotal role in regulating the immune response. The induction of B cell-mediated immunosuppressive function requires B cell ...
T-cells interact with B cells, dendritic cells, and fibroblast-like ...
T cells cooperate with B cells, DCs, and FLSs to maintain the stability of the immune system under physiological conditions. However, under pathological ...
B cell checkpoints in autoimmune rheumatic diseases
T cells and B cells, respectively) to disrupt TFH cell–. B ... activation, expansion, and plasma cell generation during CD4+ T cell- B cell collaboration.
Activation Markers on B and T Cells and Immune Checkpoints in ...
In addition to identifying the major B- and T-cell subpopulations involved in autoimmune rheumatic diseases (ARDs), in recent years special attention has ...
T-Cell‒Mediated Autoimmunity: Mechanisms and Future Directions
T cells are key drivers of autoimmunity in numerous noncommunicable inflammatory skin diseases by directly harming host tissue or through helping B cells in ...
Disruption of memory B-cell trafficking by belimumab in patients with ...
Autoreactive memory B cells (MBCs) contribute to chronic and progressive courses in autoimmune diseases like SLE. The efficacy of belimumab (BEL), the first ...
Cutting Edge: Direct Suppression of B Cells by CD4 + CD25 + ...
Regulatory T cells (Tregs) appear to play important roles in regulation of B cell Ig response. In several autoimmune diseases with aberrant Ab production, the ...
Genes involved in regulating T cell/B cell collaboration are ...
... Active collaboration of antigen-specific T and B cells is a common feature of many autoimmune diseases such as multiple sclerosis (MS), an inflammatory ...