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Dissection of the Dislocation Pathway for Type I Membrane Proteins ...


Dissection of the Dislocation Pathway for Type I Membrane Proteins ...

These results show that eeyarestatin I inhibits the ER-to-cytosol degradation pathway of several type I membrane proteins. Importantly, these data confirm that ...

Dissection of the dislocation pathway for type I membrane proteins ...

The mammalian endoplasmic reticulum (ER)-to-cytosol degradation pathway for disposal of misfolded proteins is an attractive target for therapeutic ...

Dissection of the Dislocation Pathway for Type I Membrane Proteins ...

PDF | The mammalian endoplasmic reticulum (ER)-to-cytosol degradation pathway for disposal of misfolded proteins is an attractive target for therapeutic.

Dissection of the Dislocation Pathway for Type I ... - Altmetric

Dissection of the Dislocation Pathway for Type I Membrane Proteins with a New Small Molecule Inhibitor, Eeyarestatin. Overview of attention for article ...

https://iccb.med.harvard.edu/bibcite/export?content_filter%5B0%5D ...

... class I MHC heavy chain counterpart. Eeyarestatin I also inhibited degradation of a second misfolded type I membrane protein, T-cell receptor alpha. Both ...

Decoupling the Role of Ubiquitination for the Dislocation Versus ...

... protein calnexin and the cytosolic protein ... 25. Fiebiger, E. ∙ Hirsch, C. ∙ Vyas, J.M. ... Dissection of the dislocation pathway for type I membrane proteins ...

Protein dislocation from the ER - ScienceDirect.com

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein ... membrane, by the ubiquitin-proteasome pathway. EMBO J., 15 (1996) ...

[PDF] The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound ...

It is shown that ES24 impairs protein secretion and membrane protein ... Dissection of the dislocation pathway for type I membrane proteins with a new small ...

Degradation of Proteins from the ER of S. cerevisiae Requires an ...

To dissect the requirements of membrane protein degradation from the ER, we expressed the mouse major histocompatibility complex class I heavy chain H-2Kb ...

Dislocation of a Type I Membrane Protein Requires Interactions ...

Cabral, C.M., Liu, Y., and Sifers, R.N. (2001). Dissecting glycoprotein quality control in the secretory pathway.Trends Biochem. Sci.26,619–624. https://doi.org ...

Substrate ubiquitination retains misfolded membrane proteins in the ...

In eukaryotes, approximately one-third of the proteome enters the secretory pathway at the endoplasmic reticulum (ER). After proteins are ...

Eeyarestatin I inhibits Sec61-mediated protein translocation at the ...

Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol. Biol. Cell. 15. ,.

A glycosylated type I membrane protein becomes cytosolic when ...

N‐glycanase activity is therefore not required for dislocation of glycosylated Class I MHC molecules from the ER. Introduction. Many proteins destined for ...

Dissecting the ER-Associated Degradation of a Misfolded Polytopic ...

... pathway of any membrane protein that can be expressed in yeast. ... Discussion. Polytopic membrane proteins constitute an important class of ...

Inhibitors of protein translocation across membranes of the secretory ...

... Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell 15(4): ...

HERC3 E3 ligase provides an ERAD branch eliminating ... - bioRxiv

... type of membrane proteins. Result. HERC3 limits the cell surface ... Dissecting the ER-Associated degradation of a misfolded polytopic membrane ...

Live Cell Imaging of Protein Dislocation from the Endoplasmic ...

Introduction. Proteins destined for the secretory pathway are inserted into the membrane or lumen of the endoplasmic reticulum (ER), where they are processed ...

Mechanism and components of endoplasmic reticulum-associated ...

In yeast, three distinct membrane protein complexes that define different ERAD pathways ... A membrane protein required for dislocation of misfolded proteins from ...

Molecular pathways of mitochondrial outer membrane protein ...

Thus, substrate unfolding and dislocation begins with the unfolding of an ubiquitin molecule. Mitochondria carry a set of proteolysis enzymes ...

Inhibition of protein translocation at the endoplasmic reticulum ...

Fiebiger, Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin, Mol. Biol. Cell, № 15, с ...