Distinctive populations of CD4 T cells associated with vaccine efficacy

Distinctive populations of CD4+T cells associated with vaccine efficacy

Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To distinguish features of memory cells that confer ...

T cells associated with vaccine efficacy

Distinctive populations of CD4. +. T cells associated with vaccine efficacy. Therese. Woodring, Colin. N. Dewey, Lucas. Dos Santos Dias,. Xin He ...

T cells associated with vaccine efficacy

Distinctive populations of CD4. +. T cells associated with vaccine efficacy. Therese Woodring, Colin N. Dewey, Lucas Dos Santos Dias, Xin He, Hannah E. Dobson ...

Regulation of B cell responses by distinct populations of CD4 T cells

Maturation of B cells in Germinal Centers (GC) is a hallmark in adaptive immunity and the basis of successful vaccines that protect us against lethal ...

T-cell quality in memory and protection: implications for vaccine design

In addition, recent results provide a mechanism for why distinct functional populations of cytokine-producing T cells are better effectors. We focus on the ...

Preservation of naive-phenotype CD4+ T cells after vaccination ...

Here, we examined virus-specific CD4+ T cells after YFV vaccination to delineate key features of durable CD4+ T cell responses. YFV-specific CD4 ...

Pre-existing immunity and vaccine history determine hemagglutinin ...

Here we show, by monitoring frequencies of CD4 T cells specific to the conserved hemagglutinin epitope HA118-132 and titres of IgG against the ...

Neoantigen vaccine-induced CD4 T cells confer protective immunity ...

Despite this, these vaccines have demonstrated clinical efficacy. Therefore, understanding the mechanisms of CD4 + T cell-mediated tumor protection is critical ...

Quality and Vaccine Efficacy of CD4+ T Cell Responses Directed to ...

The vaccine-promoted response consists mainly of double- (TNF-α and IL-2) or triple-positive (IFN-γ, TNF-α, and IL-2) polyfunctional T cells. This ...

The Major Role of T Regulatory Cells in the Efficiency of Vaccination ...

Insightful studies have uncovered the complexities of different functional networks of CD4 T cells (T helper 1 (Th1); Th2, Th17) and CD8 T cells (T cytotoxic; ...

Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to ...

Taken together, our data provide strong evidence for distinct HIV susceptibility of CD4 T cells induced by different vaccine vectors and highlight the ...

Novel populations of CD4+T cells associated with vaccine efficacy ...

We also detected a unique population enriched in protection that highly expressed the gene for the natural killer cell marker NKG7. Lastly, we detected ...

The roles of resident, central and effector memory CD4 T‐cells in ...

CD4 T-cells play a central role in all adaptive immune responses. Vaccines must, therefore, activate CD4 T-cells if they are to generate ...

Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable ...

The most effective adjuvant/vaccine combinations elicited multifunctional CD4 T cell responses and a Th1-skewed antibody response. By transferring antigen- ...

Features of Effective T Cell-Inducing Vaccines against Chronic Viral ...

... T cells is related to the ... T cell populations have the same efficacy on a per-cell basis. ... CD4+ and CD8+ T cell population after immunization.

CD4+CCR6+ T cells dominate the BCG-induced transcriptional ...

A large number of immune response genes and pathways were upregulated post BCG vaccination with similar patterns observed in both PBMCs and ...

Skewed representation of functionally distinct populations of virus ...

In addition to the critical antiviral role played by CD8 T cells,1 the importance of virus-specific CD4 T cells and its association with a protective antiviral ...

A Review of the Relationship between CD4 T-lymphocytes and ...

Our review found that the CD4 cell count in PLWH is correlated with the efficacy of SARS-CoV-2 vaccines, and the number CD4 cell could decline ...

SARS-CoV-2 vaccination induces a CD4 + T cell-dominant immune ...

... median frequency of circulating SARS-CoV-2-specific CD4 + T cells was 3-fold (range: 0.42-39.8) higher than CD8 + ...

CD4+ T Cell Immune Specificity Changes After Vaccination in ...

The analysis of SARS-CoV-2-induced T cell activation pre-vaccination showed that 40% HD displayed activation of CD4+T cells in the presence of ...