Distinctive tumorigenic significance and innovative oncology targets ...

Protein SUMOylation, a post-translational modification, intricately regulates diverse biological processes including gene expression, ...

This review focuses on elucidating the fundamental regulatory mechanisms and pathological functions of the SUMO pathway in tumor pathogenesis and malignant ...

Distinctive tumorigenic significance and innovative oncology targets ...

SUMOylation, identified in the 1990s, is a dynamic and reversible protein post-translational modification. In a nutshell, this process is a multi-step enzymatic ...

Distinctive tumorigenic significance and innovative oncology targets ...

Distinctive tumorigenic significance and innovative oncology targets of SUMOylation ... To read the full-text of this research, you can request a ...

Distinctive tumorigenic significance and innovative oncology targets ...

(2024) Zhou et al. Theranostics. Protein SUMOylation, a post-translational modification, intricately regulates diverse biological processes including gene ...

Emerging Targets and Therapeutics in Immuno-Oncology

Among the different types of emerging therapies, kinase inhibitors, immune checkpoint-based therapies, cancer vaccines, ADCs, CAR, and tumor ...

Emerging Tech for IO Targeting and Discovery

Tumor and immune phenotypes mediate therapeutic efficacy for most solid tumors. However, there is not a widely available method to measure immune phenotypes for ...

Cancer drug discovery accelerated as hundreds of overlooked ...

A new, systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types, including breast, lung and ovarian cancers.

New clinical trial design in precision medicine - Nature

... carcinoma: An NRG oncology/gynecologic oncology group study. Gynecol ... Apatinib targets both tumor and endothelial cells in hepatocellular ...

Tumor Is Not the Only Target: Ensuring Equitable Person-Centered ...

Living with cancer is life-altering, no matter what the outcome. Supporting patients and families through this unique experience requires ...

Targeting the tumor microenvironment: Potential strategy for cancer ...

In recent years targeting the TME has developed as a potential strategy for treatment of cancer because of its life-threatening functions in restricting tumor ...

Targeting the tumor stroma for cancer therapy

Taken as a whole, while the stromal composition vary across distinct cancer types, some major components are indispensable for solid tumors, ...

Drug repurposing for cancer therapy - Nature

3). Accumulating evidence has highlighted the potential of using repurposed drugs to restrict tumor growth. These drugs have been shown to ...

NCI-supported Precision Medicine Oncology Research Activities

NCI promotes research to discover unique therapies that treat an individual's cancer based on the specific genetic abnormalities of that ...

Molecular profiling for precision cancer therapies | Genome Medicine

The number of druggable tumor-specific molecular aberrations has grown substantially in the past decade, with a significant survival benefit ...

Addressing the Right Targets in Oncology: Challenges and ...

In this review, we suggest that early oncology drug discovery should focus on selection and prosecution of cancer targets with strong disease biology.

Project SignifiCanT: Statistics in Cancer Trials - FDA

Project Significant (Statistics in Cancer Trials) established by the FDA Oncology Center of Excellence, promotes collaboration and engagement among diverse ...

Research Areas: Treatment - National Cancer Institute

The NCI-60 Human Tumor Cell Lines Screen, which includes 60 human tumor cell lines representing nine different types of cancer, is a free ...

Oncology – AstraZeneca - Redefining Cancer Care

Our Oncology strategy is built with one goal in mind – to push the boundaries of science to change the practice of medicine and transform the lives of patients ...

Cancer Innovation - Wiley Online Library

A new frontier in innovative oncology solutions. · Presenting a unique combination of oncology research, innovation, and data. · A hub for collaboration and ...