Divergence in the metabolome between natural aging and ...

Divergence in the metabolome between natural aging ... - PubMed

AD mice exhibited memory deficits across age and these memory deficits were also seen in naturally aged mice. Prefrontal cortex (PFC), ...

Divergence in the metabolome between natural aging and ... - Nature

Here, we used an untargeted metabolomics analysis to define system-level alterations following cognitive decline in aged and APP/PS1 (AD) mice.

Divergence in the metabolome between natural aging ... - ProQuest

AD mice exhibited memory deficits across age and these memory deficits were also seen in naturally aged mice. Prefrontal cortex (PFC), hippocampus (HPC), and ...

Author Correction: Divergence in the metabolome between ... - Nature

Author Correction: Divergence in the metabolome between natural aging and Alzheimer's disease ... The Supplementary Information published with ...

Author Correction: Divergence in the metabolome between natural ...

This corrects the article "Divergence in the metabolome between natural aging and Alzheimer's disease", 12171. Correction to: Scientific Reports 10.1038 ...

Author Correction: Divergence in the metabolome between natural ...

www.nature.com/scientificreports. Author Correction: Divergence in the metabolome between natural aging and Alzheimer's disease. Holly C. Hunsberger, Bennett ...

Divergent remodeling of the skeletal muscle metabolome over 24 h ...

We find that metabolites associated with the initial steps of glycolysis and hexosamine biosynthesis are higher in OMC men around the clock, ...

S-EPMC7655935 - Author Correction: Divergence in the ... - OmicsDI

Author Correction: Divergence in the metabolome between natural aging and Alzheimer's disease. Hunsberger Holly C HC Greenwood Bennett P BP Tolstikov ...

Metabolomics in aging research: aging markers from organs

And cells also continue to generate endogenous ROS during normal metabolism (Sarniak et al., 2016). It is generally believed that the latter is the main reason ...

How do metabolic processes age: Evidence from human ...

They summarized their findings into major pathways of metabolomic aging and, despite the acknowledged difficulties in comparing results across metabolomic ...

Divergent remodeling of the skeletal muscle metabolome over 24 h ...

metabolome between metabolically healthy versus metaboli- cally compromised aging. ... quality in each sample, as large natural variance ...

Strain Summary for Reference : J:294065 - Mouse Genome Informatics

Hunsberger HC, et al., Divergence in the metabolome between natural aging and Alzheimer's disease. Sci Rep. 2020 Jul 22;10(1):12171 ...

(PDF) Metabolomics of Aging and Alzheimer's Disease: From Single ...

Hunsberger, B. P. Greenwood, V. Tolstikov, N. R. Narain, M. A. Kiebish, and C. A.. Denny, "Divergence in the metabolome between natural aging and Alzheimer' ...

Divergent serum metabolomic, skeletal muscle signaling ...

An estimated 63% of mitochondrially localized proteins contain lysine acetylation sites (25), and although the NAD+-dependent nature of SIRT deacetylase ...

Metabolic drift in the aging brain

The observed changes in opposing directions result in loss of biochemical balance among metabolites within specific functional subsets or biological pathways ...

Unbiased Metabolomic Investigation of Alzheimer's Disease Brain ...

Divergence in the metabolome between natural aging and Alzheimer's disease. Scientific Reports 2020, 10 (1) https://doi.org/10.1038/s41598 ...

A metabolome atlas of the aging mouse brain - eScholarship

metabolome between the sexes (Supplementary Fig. 2a). ARTICLE. NATURE COMMUNICATIONS | https://doi.org/10.1038/s41467-021-26310-y. 2. NATURE COMMUNICATIONS ...

Principles of metabolome conservation in animals - PNAS

Overall, this study uncovers simple rules that govern metabolic evolution in animals and implies that most tissue metabolome differences between species are ...

KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of ...

Among them, it is interesting to note that serine, an amino acid and coagonist of NMDA receptors, improves synaptic plasticity in the normal ...

High-Throughput Metabolomics for Discovering Potential ... - Frontiers

Three pathways (purine metabolism, arginine and proline metabolism, and the TCA cycle) were shared between aging and AD. Arginine and proline metabolism play a ...