Divergent tumor and immune cell reprogramming underlying ...

Our data depicts specific reprogramming of macrophage, T cells and tumor cells associated with ICI response and irAEs, elucidates divergent roles of TNF ...

Divergent tumor and immune ... reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma.

[PDF] Divergent tumor and immune cell reprogramming underlying ...

Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma · 6 Citations.

(PDF) Divergent tumor and immune cell reprogramming underlying ...

PDF | Background Lung squamous cell carcinoma (LUSC) remains a leading cause of cancer-related deaths with few therapeutic strategies.

Metabolic Reprogramming Induces Immune Cell Dysfunction in the ...

Metabolic reprogramming is considered a hallmark of cancers and metabolism is altered in most, if not all cancer cells, regardless of the type ...

Reprogramming the tumor immune microenvironment using ... - Nature

... immune cell cells in both primary tumors and metastatic livers. ... In addition, we clarified the molecular mechanisms underlying the induction of ...

Divergent immune microenvironments in two tumor nodules from a ...

Immune cell deconvolution suggested that the hot nodule was enriched not only in CD8+ and CD4 + T lymphocytes, but also in M1 macrophages, ...

Metabolic Reprogramming of Immune Cells in Cancer Progression

Although the mechanism(s) behind the impaired ... 78. Mancino, A. ∙ Schioppa, T. ∙ Larghi, P. ... Divergent effects of hypoxia on dendritic cell functions.

GITR and TIGIT immunotherapy provokes divergent multicellular ...

... cell type-specific transcriptional reprogramming in response to immunotherapy perturbations. ... Single-cell tumor-infiltrating immune cell atlas ...

Reprogramming Immune Cells for Enhanced Cancer Immunotherapy

Here, we summarize the key roles of different immune cells in the tumor microenvironment and emerging immunotherapy strategies based on modulation of different ...

Metabolic Reprogramming of Immune Cells in Cancer Progression

Although the mechanism(s) behind the impaired functionality of ... Divergent effects of hypoxia on dendritic cell functions. Blood, 112 ...

Metabolic Reprogramming of Tumor-Associated Macrophages ...

Clusters at the subset level were manually annotated based on basic ... Divergent metabolic reprogramming in T cells relative to cancer cells in the ...

Glutamine blockade induces divergent metabolic programs to ...

The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, ...

The Role of Tumor Metabolic Reprogramming in Tumor Immunity

The Effects of Glucose Metabolism on Immune Cells. Glucose is among the primary energy sources underlying the proliferation of tumors. As mentioned earlier, ...

The cancer metabolic reprogramming and immune response

For instance, the metabolism of naïve T cell is basically static, showing zero proliferation, so only the most basic nutrient intake, minimum ...

Tumor cell metabolic reprogramming and hypoxic immunosuppression

Here, we cover the regulation of the antitumor immune response by metabolic reprogramming in cancer cells and immune cells as well as potential strategies for ...

Spatiotemporal single-cell analysis decodes cellular dynamics ...

... underlying different responses to immunotherapy in ... Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma.

Deciphering the complexities of cancer cell immune evasion

... tumor cell migration along with immune reprogramming of the TME [248]. Moreover, hypoxia-induced cells (CAFs, TAMs and cancer cells) in the ...

Deciphering the Warburg Effect - Annual Reviews

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. ... Glutamine blockade induces divergent metabolic programs to overcome tumor ...

OUCI

Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma. Minjiang ...