Drug|induced QT prolongation and Torsades de Pointes

Drug-Induced QT Prolongation And Torsades de Pointes - PMC

Torsades de pointes (TdP)—an uncommon but life-threatening polymorphic ventricular tachycardia—is almost always drug induced. The authors describe the causes, ...

Drug induced QT prolongation and torsades de pointes - PMC

Since 1986, certain non-sedating antihistamines, the so called second generation antihistamines (mainly terfenadine and astemizole), have been reported to cause ...

Medication-Induced QT-Interval Prolongation and Torsades de Pointes

Drug-induced QT prolongation acts as a marker for risk of progression to TdP. However, drug-induced QT-interval prolongation does not always progress to TdP.

Drug-induced QT prolongation and Torsades de Pointes - the facts

QT prolongation, a surrogate marker for the risk of developing TdP, is an established side effect of Class I and Class III anti-arrhythmic medicines. It is also ...

Drug-induced QT prolongation and torsade de pointes - Frontiers

Introduction: Drug-induced QT prolongation and (or) Torsade de Pointes (TdP) is a well-known serious adverse reaction (ADR) for some drugs, ...

Drug induced QT prolongation and torsades de pointes - BMJ Heart

An increasing number of drugs, especially non-cardiac drugs, have been recognised to delay cardiac repolarisation and to share the ability with class III ...

Prevention of Torsade de Pointes in Hospital Settings - AHA Journals

Administration of a QT-prolonging drug to a hospitalized population may be more likely to cause TdP than administration of the same drug to an ...

Managing drug-induced QT prolongation in clinical practice

Many drug therapies are associated with prolongation of the QT interval. This may increase the risk of Torsades de Pointes (TdP), a potentially life- ...

Current concepts in the mechanisms and management of drug ...

Drug-induced long QT syndrome (LQTS) is characterized by acquired QT interval prolongation and increased risk of torsade de pointes (TdP). In 1964, Selzer and ...

Pharmacological treatment of acquired QT prolongation and ...

Torsades de pointes (TdP) is a characteristic polymorphic ventricular arrhythmia associated with delayed ventricular repolarization as ...

What Clinicians Should Know About the QT Interval - JAMA Network

Context Of the several factors implicated in causing QT interval prolongation and torsades de pointes, errors in the use of medications that may prolong ...

Predicting the Unpredictable: Drug-Induced QT Prolongation and ...

diLQTS is associated with a special form of ventricular tachycardia (VT) called torsades de pointes (TdP), which can be transient and cause a reversible syncope ...

Drug-induced QT prolongation and torsades de pointes

The QT nomogram is a clinically relevant risk assessment tool that accurately predicts arrhythmogenic risk for drug-induced QT prolongation.

Drug-induced torsades de pointes: Disproportionality analysis of the ...

In general, TdP is associated with prolonged QT interval, for every 10 ms increase in QT interval, the risk of TdP increases by approximately 5–7% (6). Long QT ...

Drug-induced QT prolongation - Wikipedia

Excessive QT prolongation can trigger tachycardias such as torsades de pointes (TdP). QT prolongation is an established side effect of antiarrhythmics, but can ...

Predicting drug‐induced QT prolongation and torsades de pointes

Abstract. Drugs used to treat cardiovascular disease as well as those used in the treatment of multiple other conditions can occasionally ...

Overview of Long QT Syndrome and Torsades de Pointes

The risk of TdP increases when the QT interval is markedly prolonged (>500 msec) or when QT prolongation is combined with other risk factors ...

Drug-Induced QT Prolongation - U.S. Pharmacist

This surplus of positively charged ions leads to an extended repolarization phase, thus resulting in a prolonged QT interval, causing ...

Torsade de Pointes - Medscape Reference

Women have longer QT intervals, as well as have more QT prolongation secondary to drug therapy. Congenital long QT syndrome is ...

Drug-induced Prolongation of the QT Interval - AAFP

There is an increased risk for the development of torsades de pointes, a potentially fatal arrhythmia, when the QT interval is prolonged.