Drug resistance mechanisms and treatment strategies mediated by ...

Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets.

Current Drug Resistance Mechanisms and Treatment Options in ...

Despite the success of TKI therapy, challenges such as drug resistance and disease progression remain persistent. The mechanisms of drug ...

Treatment strategies and drug resistance mechanisms in ...

Although the underlying molecular mechanisms involved in drug resistance of adenocarcinoma vary from one organ to the other, there are several targets that are ...

Hallmarks of cancer resistance: iScience - Cell Press

Pharmacogenomics (the study of how drugs work in the body) explores the genetic influence on drug response, particularly in cancer treatment, ...

Understanding and targeting resistance mechanisms in cancer

However, acquired drug resistance is developed after receiving cancer treatment, which is generally mediated by the adaptive alterations against ...

Unveiling the mechanisms and challenges of cancer drug resistance

Anti-cancer treatment strategies are evolving due to innate and acquired resistance capacity, governed by genetic, epigenetic, proteomic, ...

Multidrug Resistance in Cancer: Understanding Molecular ...

This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies

Multidrug Resistance - an overview | ScienceDirect Topics

Multidrug Resistance ; Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies. Wen Li, ... Zhe- ...

Diverse drug-resistance mechanisms can emerge from drug-tolerant ...

Random, resistance-conferring genetic events preceding drug treatment are an unquestionable means by which this diversity can occur. Yet, ...

Targeted Therapy and Mechanisms of Drug Resistance in Breast ...

Intrinsic resistance occurs before treatment and can be caused by genetic mutations, the proliferation of pre-existing insensitive subpopulations such as cancer ...

Mechanisms and strategies to overcome multiple drug resistance in ...

There are many studies to overcome MDR by inhibiting MDR transporters, to suppress or circumvent MDR mechanisms. The use of anticancer drugs ...

Drug resistance and combating drug resistance in cancer

Therapeutic effects of a drug can be reduced by activation of intrinsic pathways that are used as a defense against environmental toxins, including anticancer ...

Mechanisms of resistance to targeted therapy and immunotherapy in ...

Promising strategies for overcoming resistance include the development of combination therapies, understanding the resistance mechanisms to better use novel ...

Strategic Combinations to Prevent and Overcome Resistance to ...

Another pathway-independent mechanism of resistance to targeted therapy consists of apoptosis evasion, achieved by an imbalance between pro- and antiapoptotic ...

Tumor cell plasticity in targeted therapy-induced resistance - Nature

Notably, up to 90% cancer-associated deaths are attributed to drug resistance. Acquired drug resistance can be induced by targeted treatments ...

Emerging Therapeutic Strategies to Overcome Drug Resistance in ...

This review investigates the latest advancements in overcoming drug resistance mechanisms employed by cancer cells, focusing on emerging therapeutic modalities.

Drug Resistance | Microbiology - Lumen Learning

Microbes may develop resistance mechanisms that involve inhibiting the accumulation of an antimicrobial drug, which then prevents the drug from reaching its ...

Mechanisms of Resistance to Antibody–Drug Conjugates

Abstract. Drug resistance limits the effectiveness of cancer therapies. Despite attempts to develop curative anticancer treatments, tumors evolve evasive.

Drug resistance - Wikipedia

Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition.

DRMref: comprehensive reference map of drug resistance ...

Notably, DRMref investigates the drug resistance mechanisms (e.g. Aberration of Drug's Therapeutic Target, Drug Inactivation by Structure ...