Drugging The Undruggable Strategies And Future Directions

Advances in small molecule drug discovery are allowing us to rethink and expand the list of therapeutic targets that may be druggable in oncology.

Recent advances in targeting the “undruggable” proteins: from drug ...

According to the mechanism of undruggable proteins, some major strategies for drug design has been formed correspondingly, including covalent ...

Stephen Fawell posted on the topic | LinkedIn

Stephen Fawell, this is a fantastic and insightful article on the advancements and challenges in drugging the "undruggable" targets in oncology.

Emerging Pharmacotherapeutic Strategies to Overcome ... - NCBI

The drug development strategies to overcome the undruggable targets and current challenges in targeted therapies were also summarized. There are ...

Drugging the undruggable Ras: mission possible? - PMC

However, there is renewed hope that this is not the case. In this review, we summarize the progress and promise of five key directions. First, we focus on the ...

Drugging the Undruggable: Advances on RAS Targeting in Cancer

Despite this, there is a deficiency of RAS-targeting agents licensed for therapeutic use. The picomolar affinity of RAS for GTP, and the lack of suitable ...

Five strategies for drugging the undruggable - STAT News

Thousands of molecules in the body are known to influence disease, but creating medicines that can interact effectively with most of them is ...

TPD: turning undruggable targets into druggable targets

TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. Unlike traditional drug ...

Drugging the 'undruggable' cancer targets - Shokat Lab

Peptide therapeutics: current status and future directions. Drug Discov. Today. 20, 122–128 (2015). 47. Kapoor, A. et al. Yap1 activation ...

Undruggable: The Current State of Drugging Cancer Targets

Future directions. Scientists are using two new innovative approaches: peptide stapling and fragment-based drug discovery. These methods help ...

Review Drugging the undruggable: Transcription therapy for cancer

Abstract · Introduction · Section snippets · Transcriptional regulation and targeting strategies · DNA-binding small molecules · Targeting protein–protein ...

Cancer Medicine Call for Papers Drugging the undruggable

This special issue will detail new approaches to target proteins in cancer, previously deemed undruggable, raising the exciting possibility of novel ...

The Future of Drug Discovery: Tackling the Undruggable with New ...

In the constantly evolving field of drug discovery, the term “undruggable” refers to proteins and targets in the body that, until recently, ...

Taking Aim at the Undruggable

8 This was the first story of successful drug development against a transcription factor. ... Collateral lethality: a new therapeutic strategy in ...

Strategies for targeting undruggable targets - Taylor & Francis Online

Undruggable targets refer to clinically meaningful therapeutic targets that are 'difficult to drug' or 'yet to be drugged' via traditional approaches.

Drugging the undruggable proteins in cancer: A systems biology ...

... ... [20] [21] [22][23] According to the mechanism of undruggable proteins, some major strategies for drug design has been formed ...

Drugging the 'undruggable'. Therapeutic targeting of protein–DNA ...

Keynote (green). Drugging the 'undruggable'. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods.

KRAS mutation: from undruggable to druggable in cancer - Nature

Unfortunately, despite 40 years of proprietary drug efforts, there are still no effective strategies targeting KRAS mutations, except for ...

Taking Aim at the Undruggable | American Society of Clinical ...

New Technologies and Pharmacologic Entities Enable Drugging the Undruggable ... Along with tumor heterogeneity and drug-resistance mechanisms, ...

Understanding Undruggable Targets Challenges And Progress

We are discovering new ways of targeting oncogenes and degrading proteins, paving the way for an era of drug discovery where we can reach ...