Drugging Undruggable Molecular Cancer Targets

Drugging Undruggable Molecular Cancer Targets - PubMed

Drugging Undruggable Molecular Cancer Targets. Annu Rev Pharmacol Toxicol ... Keywords: RAS; cancer drug targets; oncogenes; phosphatases; transcription factors.

Drugging Undruggable Molecular Cancer Targets | Annual Reviews

Drugging Undruggable Molecular Cancer Targets. John S. Lazo1, and Elizabeth R. Sharlow1. View Affiliations Hide Affiliations. Affiliations: Fiske Drug ...

Drugging the 'undruggable' cancer targets | Nature Reviews Cancer

Our efforts have led to progress on drugging one particular allele, KRASG12C, by relying on the presence of a nucleophilic cysteine residue for ...

Drugging the 'undruggable' cancer targets - PubMed

Drugging the 'undruggable' cancer targets. Nat Rev Cancer. 2017 Aug ... Molecular Targeted Therapy*; NF-kappa B; Neoplasms / drug therapy ...

Recent advances in targeting the “undruggable” proteins: from drug ...

Although the stalemate is changing with the emergence of approved preclinical even clinical drugs for specific cancers, drug resistance poses ...

The Challenge of Drugging Undruggable Targets in Cancer

The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members ... drug-like molecules (5–7). On the ...

Undruggable: The Current State of Drugging Cancer Targets

... molecular complexities of cancer cells and provided innovative tools for drug discovery. ... Drugging the 'undruggable' cancer targets.

Taking Aim at the Undruggable | American Society of Clinical ...

In cancer, many validated drug targets are druggable with small molecules ... Drugging undruggable molecular cancer targets. Annu Rev Pharmacol ...

Drugging Undruggable Targets | Molecular Cancer Therapeutics

Gregory Verdine; Drugging "Undruggable" Targets. Mol Cancer Ther 1 November 2007; 6 (11_Supplement): CN03–02. Download citation file: Ris ...

Targeting “Undruggable” Proteins That Drive Cancer | The AACR

Also of Interest: RAS as an 'Undruggable' Drug Target · The End Game: Targeting Telomere Processing in Cancer · Landmarks in Cancer Research: ...

Novel Technology Finds New Targets Among So-Called 'Undruggable'

It is just yet to be drugged. As a result, we have developed a revolutionary technology that allows us to access these so-called undruggable ...

Drugging the undruggable proteins in cancer: A systems biology ...

Drugging the undruggable proteins in cancer: A systems biology approach · Abstract · Introduction · Section snippets · Binding-based drug discovery assays · Mass ...

Drugging Undruggable Molecular Cancer Targets - Annual Reviews

A large number of extracellular and intracellular molecular cancer targets have drugs ... Drugging the undruggable RAS: mission possible ...

Education Session to Discuss Targeting “Undruggable” Cancer ...

“The concept of undruggable targets is really thinking about targeting the key drivers of cancer from a treatment/drug perspective, which have ...

Drugging The Undruggable Strategies And Future Directions

Drugging The Undruggable: Strategies And Future Directions ... We recently described how advances in small molecule drug discovery are allowing us ...

Cancer Medicine Call for Papers Drugging the undruggable

Drugging the undruggable - new approaches to anti-cancer drug · Submission deadline: Wednesday, 31 July 2024 · Topics of interest include but are not ...

Unlocking the Potential of Undruggable Targets in Drug Discovery

Unlocking the Potential of Undruggable Targets in Drug Discovery · Overview · RAS Biology · Induced Proximity: The Future of Molecular Intervention · Deciphering ...

Scientists discover chemical probes for previously 'undruggable ...

Seeing Double: Designing Drugs That Target 'Twin' Cancer Proteins. Oct. 1, 2024 — Some proteins in the human body are easy to block with a drug ...

Emerging Pharmacotherapeutic Strategies to Overcome ...

Trends in Modern Drug Discovery. Handb Exp Pharmacol. 2016;232:3-22. 11. Lazo JS, Sharlow ER. Drugging Undruggable Molecular Cancer Targets. Annu Rev ...

Drugging the 'undruggable'. Therapeutic targeting of protein–DNA ...

Top2 is highly overexpressed in a variety of cancer cells and remains an important drug target; several widely used FDA-approved drugs act by forming genotoxic ...