Drugging the 'undruggable' cancer targets

Drugging the 'undruggable' cancer targets | Nature Reviews Cancer

Pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new ...

Drugging the 'undruggable' cancer targets - PubMed

Pharmacologically targeting these intractable proteins is now a key challenge in cancer research that requires innovation and the development of new ...

Recent advances in targeting the “undruggable” proteins: from drug ...

The term “undruggable” refers to target proteins whose functional interfaces are flat and lack defined pockets for ligand interaction, making ...

Drugging the "Undruggable" genes - Enzo

Undruggable cancer genes · They are widely expressed and have a key role in normal cell function, hence a high risk of off-target effect. · They are located ...

Novel Technology Finds New Targets Among So-Called 'Undruggable'

... cancer targets that could lead to new anti-cancer drugs ... drug targets among cancer proteins previously considered as undruggable.

Targeting “Undruggable” Proteins That Drive Cancer | The AACR

... undruggable protein targets” to treat cancers ... RAS as an 'Undruggable' Drug Target · The End Game: Targeting Telomere ...

Education Session to Discuss Targeting “Undruggable” Cancer ...

In a joint Education Session between ASCO and the American Association for Cancer Research (AACR) entitled, “Drugging the 'Undruggable' Target: ...

Drugging Undruggable Molecular Cancer Targets - PubMed

Cancer, more than any other human disease, now has a surfeit of potential molecular targets poised for therapeutic exploitation.

Undruggable: The Current State of Drugging Cancer Targets

The term 'undruggable' refers to proteins or targets that are challenging to target with conventional drugs. In recent years, researchers have ...

Drugging the undruggable proteins in cancer: A systems biology ...

In this review, we discuss recent integrative multiple omics approaches for understanding and modulating previously identified 'undruggable' targets.

Cancer Medicine Call for Papers Drugging the undruggable

This special issue will detail new approaches to target proteins in cancer, previously deemed undruggable, raising the exciting possibility of novel ...

Drugging Undruggable Molecular Cancer Targets | Annual Reviews

Cancer, more than any other human disease, now has a surfeit of potential molecular targets poised for therapeutic exploitation.

Taking Aim at the Undruggable | American Society of Clinical ...

In cancer, many validated drug targets are druggable with small molecules or antibodies: serine/threonine/tyrosine kinases, growth factor ...

The Challenge of Drugging Undruggable Targets in Cancer

We conclude that peptide stapling and fragment-based drug discovery show promise to traverse the critical surface features of proteins that drive human cancer.

Drugging the 'undruggable' cancer targets - Middlebury College

The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these ...

Drugging the 'undruggable' cancer targets - eScholarship

Many desirable targets in cancer fall into this category, including the RAS and MYC oncogenes, and pharmacologically targeting these intractable proteins is now ...

Investigating undruggable targets in cancer research

Key proteins belonging to difficult-to-drug targets in cancer are often known oncogenes or tumour suppressors. These include transcription ...

Emerging Pharmacotherapeutic Strategies to Overcome ...

Drugging Undruggable Molecular Cancer Targets. Annu Rev Pharmacol Toxicol ... Drugging the 'undruggable' cancer targets. Nat Rev Cancer. 2017;17:502-8.

Using AI Approaches to Target Undruggable Cancer ... - NCI Events

... Cancer Institute (NCI), Department of Energy (DOE), Advanced Research Projects Agency for Health (ARPA-H), and Food and Drug Administration (FDA). The goal ...

Drugging the Undruggable Cancer Targets - YouTube

Presented By: Dr. Ming Liu Speaker Biography: Dr. Ming Liu is a Senior Vice President of Shanghai ChemPartner and is the head of the Biology ...